This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I Project tests the feasibility of applying Agile Sciences' technology to decreasing or eliminating biofouling on filtration membranes used for drinking… More

DESCRIPTION (provided by applicant): Dental caries, or tooth decay, affects hundreds of millions of people each year, and is second only to the common cold in its prevalence world-wide. New therapeutics to aid in the prevention of dental caries would repr esent a significant advancement in oral… More

DESCRIPTION (provided by applicant): This NIH SBIR project assesses the feasibility of applying a discovery made by the cofounders of Agile Sciences, Inc. to developing a more effective therapeutic strategy toward preventing bacterial infections associated with CSF shunts. Bacterial infections… More

This Small Business Innovation Research (SBIR) Phase I project describes a new approach for reducing infections associated with indwelling medical devices. Bacteria on medical devices are particularly challenging to treat because they form a protective matrix called a biofilm on the surface of the… More

DESCRIPTION (provided by applicant): Bacterial infections are responsible for an estimated 100,000 deaths in the United States each year, and despite the dire unmet medical need, few new treatment options are being developed. One of the most significant hurdles in effectively treating bacterial… More

DESCRIPTION (provided by applicant): Chronic wounds that fail to respond to traditional therapeutic interventions afflict millions of people each year, and direct costs associated with treating these wounds are estimated at 5 to 10 billion annually. Eradication of pathogenic… More

DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is the most common life shortening inherited disorder amongst Caucasians, and Pseudomonas aeruginosa pulmonary infections are the leading cause of mortality in CF patients. Treatment of patients infected with P. aeruginosa is complicated by… More

DESCRIPTION (provided by applicant): Dental caries is one of the most prevalent diseases in the U.S. with 85% of adults and the majority of children having been treated for at least one incidence. While this disease impacts all individuals, it is especially an issue for those of low economic status… More

This Small Business Innovation Research Phase I project describes a cost-effective method for reducing the quantities of copper used for agricultural crop protection. Currently, millions of pounds of copper are being sprayed onto plants each year. This copper is released into the environment,… More

DESCRIPTION (provided by applicant): One-third of costs associated with hospital acquired infections (HAIs) are attributed to surgical site infections (SSIs), and SSIs result in a two-fold increase in patient mortality rates. SSIs are most often caused byflora from the patients skin that enter the… More