USA flag logo/image

An Official Website of the United States Government

Acute Ischemia Monitor Utilizing Subcutaneous Electrodes

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93955
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
HL096158
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Angel Medical Systems, Inc.
1163 Shrewsbury Ave., Suite E Shrewsbury, NJ -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Acute Ischemia Monitor Utilizing Subcutaneous Electrodes
Agency: HHS
Contract: 1R43HL096158-01
Award Amount: $168,483.00
 

Abstract:

DESCRIPTION (provided by applicant): We will develop a chronically implanted heart monitor that detects acute ischemia by analyzing electrocardiographic (ECG) waveforms recorded by subcutaneous electrodes. The two specific aims of this Phase I research are : (1) to further develop our ischemia detection algorithm by refining heart-rate based adjustment of ECG feature thresholds and optimizing temporal denoising and discrimination of ECG data and extracted features; and (2) to evaluate our refined ischemia de tection algorithm by comparing the extent of ECG feature changes (e.g. ST segment changes) during intervals of induced acute ischemia with changes that occur during normal daily life. The latter aim will be achieved by recruiting 36 patients and recording two datasets for each patient. The first dataset will consist of Holter recordings from three candidate bipolar leads for 1-day before patients undergo balloon angioplasty. The second dataset will consist of Holter recordings that will be obtained from the se patients during balloon angioplasty. The results of the research will be a refined and validated ischemia detection algorithm and the selection of two leads from our three candidate leads. Phase II of the project will entail creating a prototype device based on this algorithm and the chosen leads. PUBLIC HEALTH RELEVANCE: Heart attacks are the leading cause of death in the United States. Early detection of heart attacks by an implantable heart monitor will help to save lives and improve the health of sur vivors.

Principal Investigator:

Bruce Hopenfeld

Business Contact:

Andrew Taylor
bhopenfeld@angel-med.com
Small Business Information at Submission:

ANGEL MEDICAL SYSTEMS, INC.
ANGEL MEDICAL SYSTEMS, INC. 1163 Shrewsbury Ave., Suite E Shrewsbury, NJ 07702

EIN/Tax ID: 152236012
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No