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Bioactive Calcium Phosphate Glasses for Hyperthermia

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
21969
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
21969
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
MO-SCI Corp.
4040 Hy Point North Rolla, MO 65401-8277
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Bioactive Calcium Phosphate Glasses for Hyperthermia
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A new family of bioactive iron calcium phosphate glasses will be evaluated as thermoseeds for hyperthermia of cancers, especially bone tumors. Through appropriate heat treatment and atmosphere control, the Fe3+/Fe2+ ratio can be adjusted to achieve the desired magnetic hysteresis. The heat generating characteristics of these glasses under external magnetic induction will be studied as a function of glass composition, processing, sample geometry and microstructure. One or more candidate glass compositions will be identified for use in Phase II study where such material will be used in various in vitro, in vivo evaluations. Glass composition formulation takes into account of magnetic properties, bioactivity and glass forming characteristics. An appropriate balance among these properties will make such glass ideal as filler to bone defects after curettage of bone tumors, as filler in bone cements, and at the same time it is used as thermoseeds. In addition, iron calcium phosphate glasses can be made resorbable.

Principal Investigator:

Yongren B. Peng
3143642338

Business Contact:

Small Business Information at Submission:

Mo-sci Corp.
P. O. Box 2 Rolla, MO 65401

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No