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Retrievable Blood Oxygen Carrier System

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
93948
Program Year/Program:
2009 / STTR
Agency Tracking Number:
HL095250
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
NANOSHELL COMPANY, LLC
NANOSHELL COMPANY, LLC 1747 E BEECHWOOD DR LAYTON, UT 84040-
View profile »
Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: Retrievable Blood Oxygen Carrier System
Agency: HHS
Contract: 1R41HL095250-01A1
Award Amount: $357,318.00
 

Abstract:

DESCRIPTION (provided by applicant): Responding to ever increasing need for blood substitutes, scientists have developed two types of artificial oxygen carriers (AOC), polymeric hemoglobin and perfluorocarbon based AOC. While they are capable of supplying oxygen to the tissue, their side effects appear to be one of the most serious and difficult to solve problems, and a novel programmatic approach to this issue might be needed to meet the urgent need. The underlying hypothesis of this project is that if an AOC is removed promptly from the circulating blood once it is no longer needed, their side effects will be diminished, and the slow change in oxygen delivery capacity can even stimulate normal erythropoiesis. Nanoshell Company LLC is interested in developi ng a technology based on a novel shell protected nanosized perfluorocarbon based AOC developed in preliminary work by University of Utah researchers. These materials should navigate well through the small blood vessels and withstand the turbulence of circu lation. They seem to have high oxygen and carbon dioxide solubility, quickly exchange them at the tissue and lungs, and may be further coated with short chain polyethylene oxide to resist endocytosis. Because of their high density (2.0 g/ml), they are good candidate for removal by centrifugation. Our calculations suggests that the centrifugal retrieval will require two-steps of continuous flow centrifugation and the goal of this STTR project if for the University of Utah researchers to help devise a scale-u p synthesis procedure suitable for the volumes of material that are practically needed by patients, and to identify the parameters needed for their retrieval from blood obtained from a local blood bank. With these results Nanoshell Company, LLC will work w ith university researchers to design a commercializable, novel tandem continuous flow centrifugal rotor that will enable us to retrieve these AOC from the circulating blood in one-step. The separation system may also be useful to remove other existing perf luorocarbon-based AOCs, and potentially find other market niches in the separation of cells for medical use. Pending a successful conclusion of this STTR Phase I project, Nanoshell Company, and LLC will invest in construction of a high throughput synthesiz er for the retrievable AOC, as well as the fabrication of the prototype, tandem continuous flow centrifugal rotor at its Utah research facility. Nanoshell Company, LLC will then negotiate licensing rights for AOC material production, and arrange for biocom patibility and animal testing in Phase II of this project to prove efficacy and the reduction of side effects with the implementation of retrieval, in animal models, and will contract consultants to assist in the design testing procedures needed to obtain eventual FDA approval for the use of this technology. PUBLIC HEALTH RELEVANCE: The goal of this STTR project is to develop a retrievable artificial oxygen carrier (AOC) material and an optimized centrifugal retrieval system that can be safely used t o recover the AOC from the circulating blood of patients once the clinical urgency has passed.

Principal Investigator:

Agnes E. Ostafin
8015813413
A.OSTAFIN@UTAH.EDU

Business Contact:

Hiroshi Mixukami
mizukami32@yahoo.com
Small Business Information at Submission:

NANOSHELL COMPANY, LLC
NANOSHELL COMPANY, LLC 1747 E BEECHWOOD DR LAYTON, UT 84040

EIN/Tax ID: 151055985
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
UNIVERSITY OF UTAH
UNIVERSITY OF UTAH
75 South 2000 East
SALT LAKE CITY, UT 84112 1508
RI Type: Nonprofit college or university