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Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
89065
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
DK080529
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INNOVATIVE BIOTHERAPIES, INC.
650 Avis Drive, Suite 300 ANN ARBOR, MI -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome
Agency: HHS
Contract: 1R43DK080529-01
Award Amount: $499,870.00
 

Abstract:

DESCRIPTION (provided by applicant): An extracorporeal device, named selective cytopheretic device (SCD), has been fabricated that sequesters activated leukocytes and inhibits their release of inflammatory proteins and cytokines. Leukocytes are major contr ibutors to the pathogenesis and progression of many clinical inflammatory disorders, including the systemic inflammatory response syndrome (SIRS), sepsis and acute respiratory distress syndrome (ARDS). A large number of therapeutic approaches are under inv estigation to limit the activation and tissue accumulation of leukocytes at sites of inflammation in order to minimize tissue destruction and disease progression. This research proposal will evaluate this SCD on a well-developed porcine model of septic sho ck, SIRS and early ARDS. Various cardiovascular parameters, systemic cytokine levels, and pulmonary inflammation with bronchoalveolar lavage (BAL) parameters and time to death will be compared between treatment and sham treatment groups. The effects of mem brane surface area and efficacy of a simplified circuit system on the ongoing multiorgan dysfunction and inflammatory processes will also be assessed. This proposal may suggest a manner of altering the systemic inflammatory response and may lead to a new t herapeutic approach to sepsis, SIRS and ARDS.

Principal Investigator:

Business Contact:


dbuffington@innbio.com
Small Business Information at Submission:

INNOVATIVE BIOTHERAPIES, INC.
INNOVATIVE BIOTHERAPIES, INC. 401 W MORGAN RD ANN ARBOR, MI 48108

EIN/Tax ID: 753112918
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No