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Pattern Recognition Software for Single Cell Proteomics

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71658
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
GM071271
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INSILICOS
111 Queen Anne Ave N., #500 SEATTLE, WA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Pattern Recognition Software for Single Cell Proteomics
Agency: HHS
Contract: 1R43GM071271-01
Award Amount: $99,911.00
 

Abstract:

DESCRIPTION (provided by applicant): A new method is proposed for analyzing proteins in single cells. Advanced analytical techniques and a unique software platform are used to classify samples processed on a single-cell proteomics instrument. The research team includes seasoned experts in proteomics, analysis of multidimensional chromatography, and scientific computing; and will have access to data from leading-edge proteomics experiments. Preliminary results and experience with similar analytical systems indicate strong promise for the proposed approach. Proteomics is expected to produce breakthroughs in human health, but proteomics is inherently complex, producing data that resist analysis. Thus, new data methods and tools are required to realize the promise of proteomics. The proposed project analyzes data produced by a powerful new capillary-electrophoresis proteomics instrument that measures proteins in single cells. Esophageal biopsies from the Seattle Barrett's Esophagus Cohort are studied. There is a critical need for better diagnosis of dysplasias in Barrett's esophagus, so this research may directly lead to important diagnostic tools. More broadly, single-cell proteomics data analysis tools open up an important new avenue in systems biology, with pharmaceutical and other biological research applications.

Principal Investigator:

Erik J. Nilsson
2069794832
ERIKN@INSILICOS.COM

Business Contact:

Erik Nilsson
2069794832
ERIKN@INSLICOS.COM
Small Business Information at Submission:

INSILICOS
INSILICOS 4509 INTERLAKE AVE N, #223 SEATTLE, WA 98103

EIN/Tax ID: 412067331
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No