An Official Website of the United States Government
VIRACORE BIOSENSOR OPTIMIZATION
- Small Business Information
-
Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
-
Fiscal Year: 2002Title: VIRACORE BIOSENSOR OPTIMIZATIONAgency: HHSContract: 1R43RR016832-01Award Amount: $94,374.00
Abstract:
ViraCore's technology uses a biosensor-based technique that is capable of identifying, measuring, and characterizing drug interactions with membrane-bound receptors, a protein family targeted by 50 percent of the world's drugs. Membrane receptors such as G-protein coupled receptors (GPCRs) are difficult to study because they require a lipid environment for ative structure, each protein requires optimization, and only high affinity interactions can be measured. We use retrovirus pseudotype particles to present complex membrane proteins on a biosensor surface. We have developed a prototype of the technology, we have proven that it works, we have published the results in a top-tier scientific journal, and we are now extending its use to drug discovery. We have previously collaborated with several major pharmaceutical and biotechnology companies that have now expressed interest in the commercial use of the technology. The goal of our proposal is to: -Optimize conditions needed for efficient incorporation of GPCRs into retrovirus articles. -Optimize conditions needed to produce large quantities of retrovirus particles -Explore the range of protein types that can be incorporated into retrovirus particlesSmall Business Information at Submission:INTEGRAL MOLECULAR
INTEGRAL MOLECULAR 3701 MARKET ST, STE 340 PHILADELPHIA, PA 19104EIN/Tax ID: 233091965DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
|
Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 60119 |
Program Year/Program: 2002 / SBIR |
|
Agency Tracking Number: RR016832 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |