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VIRACORE BIOSENSOR OPTIMIZATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60119
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
RR016832
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INTEGRAL MOLECULAR
3711 MARKET ST Suite 900 PHILADELPHIA, PA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: VIRACORE BIOSENSOR OPTIMIZATION
Agency: HHS
Contract: 1R43RR016832-01
Award Amount: $94,374.00
 

Abstract:

ViraCore's technology uses a biosensor-based technique that is capable of identifying, measuring, and characterizing drug interactions with membrane-bound receptors, a protein family targeted by 50 percent of the world's drugs. Membrane receptors such as G-protein coupled receptors (GPCRs) are difficult to study because they require a lipid environment for ative structure, each protein requires optimization, and only high affinity interactions can be measured. We use retrovirus pseudotype particles to present complex membrane proteins on a biosensor surface. We have developed a prototype of the technology, we have proven that it works, we have published the results in a top-tier scientific journal, and we are now extending its use to drug discovery. We have previously collaborated with several major pharmaceutical and biotechnology companies that have now expressed interest in the commercial use of the technology. The goal of our proposal is to: -Optimize conditions needed for efficient incorporation of GPCRs into retrovirus articles. -Optimize conditions needed to produce large quantities of retrovirus particles -Explore the range of protein types that can be incorporated into retrovirus particles

Principal Investigator:

Benjamin J. Doranz
2159666018
BDORANZ@INTEGRAMOLECULAR.COM

Business Contact:

Benjamin Doranz
2159666018
BDORANZ@PORTOFTECH.COM
Small Business Information at Submission:

INTEGRAL MOLECULAR
INTEGRAL MOLECULAR 3701 MARKET ST, STE 340 PHILADELPHIA, PA 19104

EIN/Tax ID: 233091965
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No