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THE OVERALL OBJECTIVE OF THIS RESEARCH PLAN IS TO EVALUATE AND OPTIMIZE A NEW…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
5305
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
5305
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Chemical Sensors
44 Mechanic St Newton, MA 02164
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE OVERALL OBJECTIVE OF THIS RESEARCH PLAN IS TO EVALUATE AND OPTIMIZE A NEW ANALYTICAL PROCEDURE (MICROGRAVIMETRIC IMMUNOASSAY) FOR THE DETECTION AND QUANTITATION OF AN IMPORTANT BRAIN PROTEIN, MYELIN BASIC PROTEIN, WITH PROJECT-ED UTILITY IN THE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE OVERALL OBJECTIVE OF THIS RESEARCH PLAN IS TO EVALUATE AND OPTIMIZE A NEW ANALYTICAL PROCEDURE (MICROGRAVIMETRIC IMMUNOASSAY) FOR THE DETECTION AND QUANTITATION OF AN IMPORTANT BRAIN PROTEIN, MYELIN BASIC PROTEIN, WITH PROJECT-ED UTILITY IN THE DIAGNOSIS AND TREATMENT OF MULTIPLE SCLEROSIS AND ALZHEIMER'S DISEASE. THE DEVELOPMENT AND EVENTUAL COMMERCIALIZATION OF SUCH A METHODOLOGY COULD SIMPLIFY AND SPEED THE DIAGNOSIS OF A NUMBER OF MENTAL DISORDERS. THE RESEARCH PLAN INCLUDES THE CONSTRUCTION OF MICROELECTRONIC SENSORS BASED ON SURFACE ACOUSTIC WAVE TECHNOLOGY THAT INCORPORATES A POLYMER LAYER THAT PROTECTS THE SENSOR, REDUCES NONSPECIFIC BINDING, AND ALLOWS COVALENTCOUPLING OF MONOCLONAL ANTIBODIES. PROTOTYPE SENSORS WILL BE TESTED FOR FUNDAMENTAL OPERATIONAL CHARACTERISTICS. BIO- CHEMICAL REAGENTS INCLUDING MYELIN BASIC PROTEIN AND MONO- CLONAL ANTIBODIES TO THAT PROTEIN WILL BE PREPARED IN A PARALLEL PROGRAM. WHEN BOTH ARE READY, SENSORS INCORPORAT- ING THE MONOCLONAL ANTIBODIES WILL BE EVALUATED AND COMPAREDTO REFERENCE LABORATORY TECHNIQUES.

Principal Investigator:

Dr glenn j bastiaans
PRINCIPAL INVESTIGATOR
6179656950

Business Contact:

Small Business Information at Submission:

Integrated Chemical Sensors Cp
44 Mechanic Street Newton, MA 02164

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No