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METHODS FOR IMPROVING EXPRESSION OF TRANSFECTED IMMUNOGLOBULIN GENES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7106
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7106
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Chemical Sensors
44 Mechanic St Newton, MA 02164
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: METHODS FOR IMPROVING EXPRESSION OF TRANSFECTED IMMUNOGLOBULIN GENES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE AIM OF THIS RESEARCH PROPOSAL IS TO DEVELOP METHODS TO IMPROVE THE EXPRESSION OF TRANSFECTED IMMUNOGLOBULIN (IG) GENES. THE LONG-TERM GOAL IS TO IMPROVE THE YIELD OF GENETICALLY ENGINEERED ANTIBODIES OF THERAPEUTIC VALUE. PHASE I WILL INVESTIGATE TWO APPROACHES TO INCREASE EXPRESSION. ONE APPROACH IS TO IDENTIFY HOST MYELOMA CELLS THAT ARE MORE ACTIVE IN EXPRESSING TRANSFECTED IG GENES; THE OTHER APPROACH IS TO DEVELOP SCHEMES TO INCREASE THE NUMBER OF GENE COPIES THAT ARE EXPRESSED. PHASE II RESEARCH WILL IMPLEMENT THE FINDINGS OF PHASE I TO FORMULATE A METHODOLOGY AND SET UP EXPERIMENTS TO EXPRESS HIGH LEVELS OF GENETICALLY MODIFIED ANTIBODIES. THE RESEARCH THAT IS PROPOSED HERE COULD LEAD TO THE PRODUCTION OF GENETICALLY MODIFIED ANTIBODIES IN YIELDS COMPARABLE TO THAT OF HIGHLY PRODUCTIVE MYELOMA OR HYBRIDOMA CELL LINES. THIS WOULD THEN MAKE THE PRODUCTION OF GENETICALLY ENGINEERED ANTIBODIES A COMMERCIALLY FEASIBLE PROCESS.

Principal Investigator:

Marvin b hendricks phd
6178751336

Business Contact:

Small Business Information at Submission:

Integrated Chemical Sensors
44 Mechanic St Newton, MA 02164

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No