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Company Information:

Name: Integrated Genetics Inc
Address: 1 Mountain Rd
Framingham, MA 01701
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,048,244.00 21
SBIR Phase II $3,700,019.00 7

Award List:

SCREENING TEST FOR CYSTIC FIBROSIS CARRIERS

Award Year / Program / Phase: 1983 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward G. Berstein
Award Amount: $52,120.00

SCREENING TEST FOR CYSTIC FIBROSIS CARRIERS

Award Year / Program / Phase: 1984 / SBIR / Phase II
Agency: HHS
Principal Investigator: Edward G. Berstein
Award Amount: $964,843.00
Abstract:
Cystic fibrosis (cf) is a lethal genetic disease affecting the white population in the united states and europe. the goal of this project is to use recombinant dna technology to gain the information necessary to design a test for cf gene carriers. in this project lymphoblastoid cell lines will be… More

CHROMOSOME 1P ACCOUNTS FOR APPROXIMATELY 5% OF THE HUMAN GENOME.

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Katherine w. klinger , PRINCIPAL INVESTIGATOR
Award Amount: $49,124.00
Abstract:
Chromosome 1p accounts for approximately 5% of the human genome. the genes for a number of human diseases have been tentatively assigned to this region. however, firm assignment is not possible for many of these diseases, including hereditary malignant melanoma. accurate mapping of these genes… More

GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: Edward Bernstein , Principal Investigator
Award Amount: $50,000.00

GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE

Award Year / Program / Phase: 1986 / SBIR / Phase II
Agency: HHS
Principal Investigator: Edward Bernstein , Principal Investigator
Award Amount: $500,000.00
Abstract:
Huntington's disease (hd) is a progressive, neurodegenerative, autosomal dominant disease which generally manifests itself in the third to fifth decades of life. the goal of this project is to develop a genetic linkage test for the presymptomatic and prenatal diagnosis of huntington's disease. in… More

TRANSGENIC MICE PROVIDE APPROPRIATE MODEL SYSTEMS TO STUDY THE GENESIS, MAINTENANCE, AND TRANSMISSION OF PARTICULAR TYPES OF NEOPLASMS.

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Katherine gordon , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
Transgenic mice provide appropriate model systems to study the genesis, maintenance, and transmission of particular types of neoplasms. in addition, immortalized somatic cellscan be cultured from transgenic mice in which sv-40 early region dna was introduced into embryos and was targeted in the… More

ERYTHROPOIETIN IS AN IMPORTANT HORMONE THAT REGULATES THE PRODUCTION OF RED BLOOD CELLS.

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Richard h douglas , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
Erythropoietin is an important hormone that regulates the production of red blood cells. it is produced in the kidneyin response to hypoxia. several anemias and cythemias are associated with abnormal levels of erythropoietin. the goalof this project is to develop a highly sensitive and accurate… More

THE LONG-TERM OBJECTIVE OF THE RESEARCH DESCRIBED IN THIS APPLICATION IS TO DEVELOP A UNIQUE TECHNOLOGY FOR THE TRANS-FER OF CLONED GENES INTO THE BOVINE GERM LINE.

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Katherine gordon , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
The long-term objective of the research described in this application is to develop a unique technology for the trans-fer of cloned genes into the bovine germ line. in the long term, selection of genes to be introduced will be aimed at promoting animal longevity, disease resistance, accelerated… More

RAPID DIAGNOSTIC TEST FOR HUMAN FUNGAL PATHOGENS

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey F Lemontt , Principal Investigator
Award Amount: $50,000.00

SPECIFIC ANTIBODIES TO HUMAN AND ANIMAL POLYOMA VIRUS TUMOR

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dr Alan E Smith , Principal Investigator
Award Amount: $50,000.00

CLONING AND EXPRESSION OF HUMAN TSH

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Scott c chappel phd
Award Amount: $47,000.00
Abstract:
Studies of the biochemistry and physiology of human thyroid-stimulating hormone (htsh) have been hampered by therecent termination of distribution of pituitary-derived reagents due to potential contamination with the infectious agents of creutzfeld-jakob disease and others. continued acquisition of… More

MULTIDRUG-RESISTANCE PATTERSN IN HUMAN TUMOR CELLS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey F Lemontt Phd
Award Amount: $50,000.00

SPECIFIC ANTIBODIES TO HUMAN AND ANIMAL POLYOMA VIRUS TUMOR

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dr Alan E Smith , Principal Investigator
Award Amount: $273,000.00
Abstract:
Bk virus (bkv), a papovavirus that is highly prevalent in the human population, is related to and shares some antigenic and biochemical properties with the better- characterized simian virus sv40. infection with bkv leads to the production of tumor or t-antigens, which, in the caseof sv40, have been… More

RAPID DIAGNOSTIC TEST FOR HUMAN FUNGAL PATHOGENS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey F Lemontt , Principal Investigator
Award Amount: $500,000.00
Abstract:
Localized and systemic mycoses caused by pathogenic fungi (e.g., the yeasts candida albicans and cryptococcus neoformans) represent a serious health threat, especially toimmunocompromised patients among whom invasive candidiasis has high morbidity and mortality. currently, identificationof fungal… More

MULTIDRUG-RESISTANCE PATTERSN IN HUMAN TUMOR CELLS

Award Year / Program / Phase: 1988 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey F Lemontt Phd
Award Amount: $500,000.00
Abstract:
New antitumor compounds identified in screening programs arefrequently ineffective against metastatic human tumors that exhibit multiple-drug resistance. to enhance the efficiencyof screening for agents likely to be effective in the treatment of such tumors, integrated genetics, inc. proposesto… More

PRODUCTION OF A HORMONE RECEPTOR COMPETITIVE ANTAGONIST

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Recent research in reproductive endocrinology has demonstrated the importance of follicle stimulating hormone (fsh) in the regulation of gametogenesis and gonadal steroidproduction. it has been shown that n-linked oligosaccharides, attached to asparagine residues at specific sites along the… More

AUTOMATED LARGE SCALE ANALYSIS OF HUMAN COSMID LIBRARIES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
The objective of the proposed research plan is to develop methods to rapidly screen, isolate, and characterize cosmid clones from human dna libraries. in phase i we will establish procedures for using a robotic workstation to automate the screening of a cosmid library prepared from a somatic cell… More

CHROMOSOME SIGNPOSTS FOR GENE MAPPING

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
The long-term goal is to clone a set of dna markers spaced every 5 centimorgans along the human genome. to achieve this goal, a novel approach has been devised to generate a set of naturally spaced chromosomal signposts. these signposts will allow rapid chromosome assignment and regional… More

INTERPHASE CYTOGENETICS: CHROMOSOME SPECIFIC DNA PROBES

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

INTERPHASE CYTOGENETICS: CHROMOSOME SPECIFIC DNA PROBES

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $462,176.00
Abstract:
Current techniques for the detection of chromosome anomaliesare time consuming and require cell culture and the preparation of metaphase chromosomes. interphase cytogenetics using in situ hybridization of fluorescent labeled dna probes is potentially rapid, relatively inexpensive, and lends itself… More

DESIGN OF MUTATIONS IN TISSUE PLASINOGEN ACTIVATOR

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00
Abstract:
Tissue plasminogen activator (tpa) is a thrombolytic agent that has been demonstrated to be efficacious for clots that cause myocardial infarction and pulmonary embolism. the agent, however, must be administered at high doses over several hours. major and minor bleeding may occur in patients treated… More

DNA AMPLIFICATION FOR THE DIAGNOSIS OF GENETIC DISEASE

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

DNA AMPLIFICATION FOR THE DIAGNOSIS OF GENETIC DISEASE

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $500,000.00
Abstract:
This research involves the application of in vitro dna amplification and specific oligonucleotide probes to the clinical analysis of genetic disease. the goal of phase i of this project is to sequence three of the more informative dna probes linked to cystic fibrosis. this sequence information will… More

DESIGN OF MODIFIED PROTEIN C BY MOLECULAR MODELING

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Parthasarathy Manavalan
Award Amount: $50,000.00
Abstract:
The coagulation cascade consists of a number of multidomain serine proteases and protein cofactors. among these are factors ix, x, and prothrombin. protein c downregulates the intrinsic coagulation pathway by inactivating factors vaand viiia. factors ix, x, and protein c are highly homologous… More

PREIMPLANTATION IDENTIFICATION OF TRANSGENIC EMBRYOS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Glenn M Monastersky
Award Amount: $50,000.00
Abstract:
The overall goal of this study is to evaluate the use of embryonic biopsy and polymerase chain reaction (pcr) amplification to identify microinjected embryos in which the foreign dna has been integrated into the genome. microinjected pronuclear embryos will be cultured to the eight-cell stage, and a… More

A TOTAL HUMAN YAC LIBRARY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Terry J Lerner
Award Amount: $50,000.00
Abstract:
It is the goal of this research to construct a representative human yeast artificial chromosome (yac) library for sale to the scientific community. this library will be a valuable resource for laboratories engaged in human genetics research and the human genome mapping project. the specific aims of… More

TARGETING OF SELECTABLE MARKERS TO ANY GENETIC LOCUS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gregory M Landes
Award Amount: $50,000.00
Abstract:
It is the long-term goal of this research to develop a method of orderly segmenting the human genome into 1-50 mb fragments. this objective can be achieved by streamlining the screening process of hybrid clones generated by chromosome fragment gene transfer. the most expeditious screening process is… More

HIGH-RESOLUTION MAPPING OF DISTAL CHROMOSOME 1P

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Katherine W Klinger
Award Amount: $50,000.00
Abstract:
The incidence of cutaneous malignant melanoma (cmm) is currently increasing faster than that of any other cancer in the united states. recent linkage studies have provided evidence that a gene for hereditary melanoma is located on chromosome 1p36, specifically between the marker loci d1s45 and pnd.… More