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GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3294
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
3294
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Genetics Inc
1 Mountain Rd Framingham, MA 01701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

HUNTINGTON'S DISEASE (HD) IS A PROGRESSIVE, NEURODEGENERATIVE, AUTOSOMAL DOMINANT DISEASE WHICH GENERALLY MANIFESTS ITSELF IN THE THIRD TO FIFTH DECADES OF LIFE. THE GOAL OF THIS PROJECT IS TO DEVELOP A GENETIC LINKAGE TEST FOR THE PRESYMPTOMATIC AND PRENATAL DIAGNOSIS OF HUNTINGTON'S DISEASE. IN PHASE I, WE WILL DEVELOP THE CAPABILITY FOR CONDUCTING A FIELD TRIAL IN PHASE II FOR THE TESTING OF INDIVIDUALS AT RISK FOR HUNTINGTON'S DISEASE BY GENETIC LINKAGE ANALYSIS. THE TECHNICAL FEASIBILITY OF IDENTIFYING PARTICULAR GENOTYPES ASSOCIATED WITH HD-LINKED POLYMORPHIC DNA MARKERS WILL BE RELIABLY AND ACCURATELY DETERMINED DURING PHASE I. PROCEDURES FOR SAMPLE COLLECTION, STORAGE, DNA EXTRACTION, AND HYBRIDIZATION WILL BE OPTIMIZED AND A PILOT REFERENCE LABORATORY FOR HAPLOTYPING WITH HD-LINKED MARKERS WILL BE ESTABLISHED. CRITICAL ELEMENTS ASSOCIATED WITH THE ADMINISTRATION OF A GENETIC LINKAGE TEST FOR HUNTINGTON'S DISEASE WILL BE IDENTIFIED AND PROCEDURES

Principal Investigator:

Edward Bernstein
Principal Investigator
6178751336

Business Contact:

Small Business Information at Submission:

Integrated Genetics
31 New York Avenue Framingham, MA 01701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No