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CHROMOSOME 1P ACCOUNTS FOR APPROXIMATELY 5% OF THE HUMAN GENOME.

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3065
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3065
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Genetics Inc
1 Mountain Rd Framingham, MA 01701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: CHROMOSOME 1P ACCOUNTS FOR APPROXIMATELY 5% OF THE HUMAN GENOME.
Agency: HHS
Contract: N/A
Award Amount: $49,124.00
 

Abstract:

CHROMOSOME 1P ACCOUNTS FOR APPROXIMATELY 5% OF THE HUMAN GENOME. THE GENES FOR A NUMBER OF HUMAN DISEASES HAVE BEEN TENTATIVELY ASSIGNED TO THIS REGION. HOWEVER, FIRM ASSIGNMENT IS NOT POSSIBLE FOR MANY OF THESE DISEASES, INCLUDING HEREDITARY MALIGNANT MELANOMA. ACCURATE MAPPING OF THESE GENES REQUIRES THE IDENTIFICATION OF ADDITIONAL MARKERS. THE-STATE-OF-THE-ART APPROACH TO HUMAN GENE MAPPING IS TO IDENTIFY RANDOM SINGLE-COPY DNA PROBES THAT DETECT DNA SEQUENCE POLYMORPHISMS, AND TO ORDER THESE POLYMORPHIC LOCI BY LINKAGE ANALYSIS. DISEASE GENES OF INTEREST ARE THEN MAPPED BY LINKAGE TO THE MARKER LOCI. THE GOAL OF THIS PROJECT IS TO USE RECOMBINANT DNA TECHNOLOGY TO DEVELOP A LIBRARY OF CHROMOSOME 1P RESTRICTION FRAGMENT LENGTH POLYMORPHISMS (RFLPS). IN PHASE I A SMALL NUMBER OF RFLPS LINKED TO THE RH LOCUS WILL BE IDENTIFIED. IN PHASE II THE

Principal Investigator:

Katherine w. klinger
PRINCIPAL INVESTIGATOR
6178751336

Business Contact:

Small Business Information at Submission:

Integrated Genetics
31 New York Avenue Framingham, MA 01701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No