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INTERPHASE CYTOGENETICS: CHROMOSOME SPECIFIC DNA PROBES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8027
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
8027
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Genetics Inc
1 Mountain Rd Framingham, MA 01701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1989
Title: INTERPHASE CYTOGENETICS: CHROMOSOME SPECIFIC DNA PROBES
Agency: HHS
Contract: N/A
Award Amount: $462,176.00
 

Abstract:

CURRENT TECHNIQUES FOR THE DETECTION OF CHROMOSOME ANOMALIESARE TIME CONSUMING AND REQUIRE CELL CULTURE AND THE PREPARATION OF METAPHASE CHROMOSOMES. INTERPHASE CYTOGENETICS USING IN SITU HYBRIDIZATION OF FLUORESCENT LABELED DNA PROBES IS POTENTIALLY RAPID, RELATIVELY INEXPENSIVE, AND LENDS ITSELF TO AUTOMATION. IT IS THE GOALOF THIS RESEARCH TO GENERATE CHROMOSOME-SPECIFIC DNA PROBES SUITABLE FOR DETECTION OF CHROMOSOMAL ANOMALIES INCLUDING NUMERICAL VARIATIONS, TRANSLOCATIONS AND DELETIONS. THE SPECIFIC AIMS OF THIS PROPOSAL ARE (1) TO SELECT A SUBSET OFCLONES DERIVED FROM CHROMOSOME 7 HTF ISLANDS LOCALIZED TO VARIOUS REGIONS OF CHROMOSOME 7 AND (2) TO EVALUATE THESE CLONES FOR THE ABILITY TO DECORATE METAPHASE AND INTERPHASE CHROMOSOMES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Integrated Genetics Inc.
1 Mountain Rd Framingham, MA 01701

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No