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CHROMOSOME SIGNPOSTS FOR GENE MAPPING

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8024
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8024
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Integrated Genetics Inc
1 Mountain Rd Framingham, MA 01701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: CHROMOSOME SIGNPOSTS FOR GENE MAPPING
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG-TERM GOAL IS TO CLONE A SET OF DNA MARKERS SPACED EVERY 5 CENTIMORGANS ALONG THE HUMAN GENOME. TO ACHIEVE THIS GOAL, A NOVEL APPROACH HAS BEEN DEVISED TO GENERATE A SET OF NATURALLY SPACED CHROMOSOMAL SIGNPOSTS. THESE SIGNPOSTS WILL ALLOW RAPID CHROMOSOME ASSIGNMENT AND REGIONAL LOCALIZATION OF UNMAPPED SEQUENCES AND GENES. FUTHERMORE, IT IS BELIEVED THAT THIS STRATEGY WILL FACILITATE ORDERED HUMAN GENOME SEQUENCING. IN PHASE I, SIGNPOSTS WILL BE GENERATED FOR HUMAN CHROMOSOME 16 CLONING A SUBSET OF HPA II A TINY FRAGMENT (HTF) ISLANDS. THE RESULTING PROBES WILL DEFINE A NEW AND EXISTING CHROMOSOME16 PROBES AND ALLOW FOR REFINEMENT OF THECURRENT CHROMOSOME 16 MAP. THESE MARKERS MAY PROVE USEFUL FOR THE DIAGNOSIS OF ADULT POLYCYSTIC KIDNEY DISEASE (APKD) IF SUCCESSFUL, THIS WILL BE THE METHOD OF CHOICE TO EXTEND THE CURRENT REPERTOIRE OF DNA MARKERS.

Principal Investigator:


0

Business Contact:

Terry Jane Lerner
5088728400
Small Business Information at Submission:

Integrated Genetics Inc
1 Mountain Rd Framingham, MA 01701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No