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Company Information:

Company Name: INTEGRATED LABORATORY SYSTEMS, INC.
City: RESEARCH TRIANGLE PARK
State: NC
Zip+4: 27709-
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,638,468.00 17
SBIR Phase II $1,710,583.00 4

Award List:

PRIMARY AROMATIC AMINES THAT WERE IMPLICATED IN BLADDER CARCINOGENESIS (BASED ON THE EPIDEMIOLOGICAL DATA WITH WORKERS IN RUBBER AND DYE INDUSTRIES) EXHIBIT SEX AND SPECIES SPECIFICITY.

Award Year / Program / Phase: 1985 / SBIR / Phase I
Agency: HHS
Principal Investigator: T. k. rao , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
Primary aromatic amines that were implicated in bladder carcinogenesis (based on the epidemiological data with workers in rubber and dye industries) exhibit sex and species specificity. urinary and bladder cancer is more prevalent in caucasian males. aromatic amines are more carcinogenic in dogs and… More

ASSAY

Award Year / Program / Phase: 1986 / SBIR / Phase I
Agency: HHS
Principal Investigator: T.k. rao , PRINCIPAL INVESTIGATOR
Award Amount: $50,000.00
Abstract:
Phase i research will examine the relationship between cytotoxicity, mutagenicity, and clastogenicity by using a number of biochemical techniques: dna adduct formation, dna/dna and dna/protein cross-linking, dna strand breaks, and sequence analysis of dna. a select group of chemical agents will be… More

DETECTION OF GERM CELL DAMAGE IN RODENTS

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Raymond R. Tice , Principal Investigator
Award Amount: $49,998.00

MECHANISMS\MICRONUCLEI INDUCTION IN MOUSE MARROW

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Tice, Raymond R , Principal Investigator
Award Amount: $50,000.00
Abstract:
Due to the speed and simplicity involved in micronuclei (mn) identification, mn analysis has become increasingly used as a sensitive, yet less expensive and time consuming alternative to classical metaphase analysis. the scoring of mn is one of the few methods currently available for the detection… More

DETECTION OF GERM CELL DAMAGE IN RODENTS

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator: Raymond R. Tice , Principal Investigator
Award Amount: $469,950.00
Abstract:
Sensitive, reproducible and cost-effective methods are needed to evaluate the potential of chemicals to induce dna damage in male and especially, female germ cells.the single cell gel (scg) electrophoresis assay is a sensitive method for detecting single strand dna breaks and alkali-liabile sites in… More

DNA DAMAGE IN SINGLE-CELLS--A BIOMARKER OF EXPOSURE

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Raymond R Tice
Award Amount: $50,000.00

DNA DAMAGE IN SINGLE-CELLS--A BIOMARKER OF EXPOSURE

Award Year / Program / Phase: 1994 / SBIR / Phase II
Agency: HHS
Principal Investigator: Raymond R Tice
Award Amount: $499,998.00
Abstract:
For the biomonitoring of dna damage in humans potentially exposed to genotoxic agents, an optimal method should be capable of detecting many classes of dna damage in a variety of cell types, should provide data at the level of the individual cell, and should be sensitive, rapid and cost effective.… More

Fiber-Induced DNA Damage & Carcinogenicity

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Bisharah Libbus
Award Amount: $76,345.00
Abstract:
The introduction and increasing use of several man-made and synthetic fibers have raisedconcern over their possible health effects in view of their similarity to asbestos, a known carcinogen.Animal studies have clearly indicated the carcinogenic effects of asbestos fibers, Furthermore, theeffects of… More

Biochemical Detection of DNA Damage in Aquatic Species

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Raymond Tice
Award Amount: $98,303.00
Abstract:
For the biomonitoring of DNA damage in aquatic species exposed to genotoxic agents, an optimal methbe capable of detecting many classes of DNA damage in a variety of cell types, should provide data aindividual cell, should be adaptable to field studies, and should be sensitive, rapid, and cost… More

Transplacental Detection of Mutagenesis

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Barbara Shane
Award Amount: $96,797.00
Abstract:
Exposure of animals and man during development can result in teratogenic, mutagenic, and carcinogenThis research will determine whether transgenic mouse models used for mutagenicity testing can be ustransplacental mutagens. Phase I will be a proof-of-principle study to demonstrate the… More

SPERMATOGONIAL MUTATIONS IN TRANSGENIC C275X174 MICE

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Donner, Maria
Award Amount: $99,989.00

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,000.00

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00

DEVELOPMENT OF THE NIEHS GENETIC ALTERATIONS IN CANCER (GAC) DATABASE

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Marcus Jackson
Award Amount: $0.00

DEVELOPMENT OF THE NIEHS GENETIC ALTERATIONS IN CANCER (GAC) DATABASE

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Marcus Jackson
Award Amount: $367,235.00

N/A

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Marcus Jackson
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Marcus Jackson
Award Amount: $373,400.00

VALIDATION OF A HUMAN CD34+ STEM CELL TOXICITY BIOASSAY

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $144,428.00
Abstract:
DESCRIPTION (provided by applicant): This SBIR application is submitted in response to the objectives of the NIEHS Predictive Test Systems for Safety Evaluation Program by developing, standardizing, and validating sensitive and specific new and novel test s or batteries of tests . Primary human… More

Integration of Genomic Biomarkers with the devTOX Human Embryonic Stem Cells Scre

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Leslie Recio – 919-544-4589
Award Amount: $149,936.00
Abstract:
DESCRIPTION (provided by applicant): Current assays employed to assess the potential of drugs and environmental agents for their potential to cause birth defects involve the use of animal models. Not only are these models costly and time consuming, but they also have poor concordance to human data.… More

Endothelial Progenitor Cells for Assessing Toxicological Response Variability in

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Cheryl A. Hobbs – 919-281-1110
Award Amount: $224,313.00
Abstract:
PROJECT SUMARY/ABSTRACT This proposed project is in response to the need for more extensive toxicological evaluation of environmental chemicals and for predictive models to assess associated risks of chemical exposure to humans. There is also need for innovative methods for evaluating the effects of… More

SBIR PHASE I TOPIC 318: CYP1B1*3 GENOTYPE AND IMPACT ON DOCETAXEL MOA; HHSN261201

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: HHS
Principal Investigator: Carol Swartz – 919-281-1110
Award Amount: $299,359.00
Abstract:
Not Available