USA flag logo/image

An Official Website of the United States Government

ASSAY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4911
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4911
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INTEGRATED LABORATORY SYSTEMS, INC.
PO BOX 13501 RESEARCH TRIANGLE PARK, NC 27709-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: ASSAY
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

PHASE I RESEARCH WILL EXAMINE THE RELATIONSHIP BETWEEN CYTOTOXICITY, MUTAGENICITY, AND CLASTOGENICITY BY USING A NUMBER OF BIOCHEMICAL TECHNIQUES: DNA ADDUCT FORMATION, DNA/DNA AND DNA/PROTEIN CROSS-LINKING, DNA STRAND BREAKS, AND SEQUENCE ANALYSIS OF DNA. A SELECT GROUP OF CHEMICAL AGENTS WILL BE EVALUATED FOR MUTAGENIC ACTIVITY IN THE MOUSELYMPHOMA (L5178Y/TK+/-) ASSAY SYSTEM BY SELECTING FOR TRIFLUOROTHYMIDINE (TFT) RESISTANCE. SMALL AND LARGE COLONYINDUCTION WILL BE CORRELATED TO CHEMICALLY INDUCED CHROMOSO-MAL ABERRATIONS AND KARYOTYPE ANALYSIS. DNA SEQUENCE ANALYSIS WILL BE PERFORMED WITH BOTH LARGE AND SMALL TK-/- MUTANT COLONIES.

Principal Investigator:

T.k. rao
PRINCIPAL INVESTIGATOR
9195444589

Business Contact:

Small Business Information at Submission:

Integrated Laboratory Systems
Po Box 13501 Rsch Triangle Park, NC 27709

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No