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Fiber-Induced DNA Damage & Carcinogenicity

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
24912
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
24912
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INTEGRATED LABORATORY SYSTEMS, INC.
PO BOX 13501 RESEARCH TRIANGLE PARK, NC 27709-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Fiber-Induced DNA Damage & Carcinogenicity
Agency: HHS
Contract: 1 R43 CA65273-1,
Award Amount: $76,345.00
 

Abstract:

The introduction and increasing use of several man-made and synthetic fibers have raisedconcern over their possible health effects in view of their similarity to asbestos, a known carcinogen.Animal studies have clearly indicated the carcinogenic effects of asbestos fibers, Furthermore, theeffects of asbestos on cultured cells include cytotoxicity and the induction of chromosome aberrationsand cell transformation. We have recently documented the induction of DNA strand damage by asbestosusing nick translation. We propose to use the induction of DNA for evaluating fiber genotoxicity andcarcinogenicity. Two techniques, nick translation and the single cell gel (SCG) assay, will be used tomeasure DNA damage induced by asbestos fibers in cultured rat mesothelial cells. The more sensitivetechnique will then be utilized to quantitate the damage induced by a number of asbestiform, man-madeand synthetic fibers. The induced damage will be correlated with animal carcinogenicity data availablefor the same fibers. Our goal is to determine the applicability of DNA damage assays to anticipatecarcinogenicity of natural and artificial fibers.

Principal Investigator:

Bisharah Libbus
9195444589

Business Contact:

Small Business Information at Submission:

Integrated Laboratorytory S
801-8 Capitola Drive Alston TE Durham, NC 27713

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No