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Transplacental Detection of Mutagenesis

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1 R43 HD33637-01,
Agency Tracking Number: 29303
Amount: $96,797.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1995
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
800-12 Capitola Drive/Alston T
Durham, NC 27713
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Barbara Shane
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

Exposure of animals and man during development can result in teratogenic, mutagenic, and carcinogenThis research will determine whether transgenic mouse models used for mutagenicity testing can be ustransplacental mutagens. Phase I will be a proof-of-principle study to demonstrate the applicabilityknown mutagen. In Phase II, the assay will be further characterized using additional chemicals and dprotocols, as well as by determining whether or not the mutant spectra of the mutagen of interest istissue of the mother and her offspring. This assay will be used to identify transplacental mutagensopportunity of determining whether mutations which occur during development are related to teratogenoutcomes.

* Information listed above is at the time of submission. *

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