USA flag logo/image

An Official Website of the United States Government

Transplacental Detection of Mutagenesis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29303
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29303
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
INTEGRATED LABORATORY SYSTEMS, INC.
PO BOX 13501 RESEARCH TRIANGLE PARK, NC 27709-
View profile »
Woman-Owned: No
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Transplacental Detection of Mutagenesis
Agency: HHS
Contract: 1 R43 HD33637-01,
Award Amount: $96,797.00
 

Abstract:

Exposure of animals and man during development can result in teratogenic, mutagenic, and carcinogenThis research will determine whether transgenic mouse models used for mutagenicity testing can be ustransplacental mutagens. Phase I will be a proof-of-principle study to demonstrate the applicabilityknown mutagen. In Phase II, the assay will be further characterized using additional chemicals and dprotocols, as well as by determining whether or not the mutant spectra of the mutagen of interest istissue of the mother and her offspring. This assay will be used to identify transplacental mutagensopportunity of determining whether mutations which occur during development are related to teratogenoutcomes.

Principal Investigator:

Barbara Shane
91944

Business Contact:

Small Business Information at Submission:

Integrated Laboratorytory S
800-12 Capitola Drive/Alston T Durham, NC 27713

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No