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Optical Fiber Microsensors for Monitoring Protein Crystal Growth

Award Information

Agency:
National Aeronautics and Space Administration
Branch:
N/A
Award ID:
56524
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
012962
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Intelligent Optical Systems, Inc.
2520 W. 237th Street Torrance, CA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: Optical Fiber Microsensors for Monitoring Protein Crystal Growth
Agency: NASA
Contract: NAS8-01164
Award Amount: $69,996.00
 

Abstract:

Intelligent Optical Systems (IOS), in collaboration with Dr. Alex McPherson and Dr. Stanley Koszelak of the University of California, Irvine, proposes to develop a family of unique sub-micron optical fiber sensors to monitor pH, temperature, and ionic strength during protein crystal growth. The proposed device combines an array of sub-micron tapered optical fibers with near?field optical (NFO) techniques and polymer-immobilized fluorescent indicators. The result is a versatile, self?referenced, multi-analyte, high-speed sensor that will be used to constantly monitor the parameters of a protein crystal growth (PCG) chamber during protein crystallization. Since small differences in pH, temperature, and ionic strength may affect the quality of the resulting crystals, it is highly desirable to monitor the solution parameters. However, because spaceborne crystal growth chambers are very small (on the order of tens of microliters), the measurement of these parameters requires the use of microscopic and sub-microscopic instrumentation that is not currently available. IOS proposes to develop a system capable of determining the influence of crystallization parameters on the size, quality, and growth rate of protein crystals in extremely small volumes. The resulting instrument will be compact enough to be used aboard space platforms, and will lead to a commercial product with medical and pharmaceutical applications.

Principal Investigator:

Claudio Egalon
Principal Investigator
3105307130
CEgalon@intopsys.com

Business Contact:

Robert A. Lieberman
Sr. Vice President & CTO
3105307130
RLieberman@intopsys.com
Small Business Information at Submission:

Intelligent Optical Systems, Inc.
2520 W. 237th Street Torrance, CA 90505

EIN/Tax ID: 954680779
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No