USA flag logo/image

An Official Website of the United States Government

HIGH-DENSITY DIGITAL MICROSPOTTING ARRAYS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
53843
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43CA090100-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Intelligent Optical Systems, Inc.
2520 W. 237th Street Torrance, CA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: HIGH-DENSITY DIGITAL MICROSPOTTING ARRAYS
Agency: HHS
Contract: N/A
Award Amount: $99,997.00
 

Abstract:

APPLICANT'S DESCRIPTION: The progression of cancer and the experimental reversal of tumorigenicity are accompanied by complex changes in the patterns of gene expression. DNA micro-arrays make it possible to quickly generate large amounts of data for gene expression monitoring, target screening, and many other applications. Understanding the function of individual genes is a challenging objective. Bioanalytical microsystems, such as immunologic and hybridization assays in micro-array format, require using high-density spotting technology that can dispense tiny (nanoliter or picoliter) quantities of solutions containing sufficient biospecific probes onto a given solid support. To achieve this objective, Intelligent Optical Systems (lOS) will develop microspotting arrays that offer millions of features with consistent spot size and spot-to-spot reproducibility, and will enable the rapid mass production of DNA chips. The proposed spotting arrays are extremely versatile. In Phase I, lOS will investigate the feasibility of MEMS-based spotting arrays by testing DNA samples and evaluating the consistency of spotted sample sizes, quantities, spot uniformity, spot density, deposition precision, minimal spot size, and the coefficient of spot-to-spot variation. PROPOSED COMMERCIAL APPLICATION: MEMS-based spotting devices will be used in the fabrication of DNA chips in many industries, such as health care and agriculture, and for food and water testing, and forensic and paternity testing. The commercial potential of this technology is very large, since it will revolutionize the fabrication of biochips, and will find use in environments ranging from clinical laboratories to biotechnology research facilities.

Principal Investigator:

Srivatsa V. Venkatasubbarao

Business Contact:


3105307130
ASHARMA@INTOPSYS.COM
Small Business Information at Submission:

INTELLIGENT OPTICAL SYSTEMS
2520 W 237TH ST TORRANCE, CA 90505

EIN/Tax ID: 954680779
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No