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BIOGRATINGS FOR COMBINATORIAL LIBRARY CHARACTERIZATION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60144
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
RR016159
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Intelligent Optical Systems, Inc.
2520 W. 237th Street Torrance, CA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: BIOGRATINGS FOR COMBINATORIAL LIBRARY CHARACTERIZATION
Agency: HHS
Contract: 1R43RR016159-01A1
Award Amount: $141,415.00
 

Abstract:

DESCRIPTION (provided by applicant): The efficiency of high throughput screening can be improved if libraries with huge diversity could be characterized for bioactivity in preliminary rounds of screening. There are currently no instruments that can characterize the bioactivities of combinatorial libraries.Intelligent Optical Systems (lOS) proposes to develop a new, inexpensive, optical instrument, based on a label less detection principle, for the rapid characterization of the bioactivities of combinatorial libraries. The proposed instrument will have sensitivities comparable to surface plasmon resonance and will measure binding events in real time. The instrument will be able to distinguish high affinity specific interactions from low affinity nonspecific binding. The proposed device consists of a laser light source, a biochip, a flow cell, a pair of detectors, and a computer for analyzing the detector's output. In Phase I, lOS will demonstrate the feasibility of using this instrument as a tool for characterizing the bioactivity of combinatorial libraries by testing the performance of the instrument through stable protein-protein interaction monitoring, transient enzyme-substrate reactions, and small molecule protein interaction.

Principal Investigator:

Srivatsa V. Venkatasubbarao
3105307130
SBIRPROPOSALS@INTOPSYS.COM

Business Contact:

Ashutosh Sharma
3105307130
ASHARMA@INTOPSYS.COM
Small Business Information at Submission:

INTELLIGENT OPTICAL SYSTEMS, INC.
INTELLIGENT OPTICAL SYSTEMS 2520 W 237TH ST TORRANCE, CA 90505

EIN/Tax ID: 954680779
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No