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Optical Nutrients Monitor for Bioreactor Applications in Zero Gravity

Award Information

Agency:
National Aeronautics and Space Administration
Branch:
N/A
Award ID:
63260
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
023947
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Intelligent Optical Systems, Inc.
2520 W. 237th Street Torrance, CA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Optical Nutrients Monitor for Bioreactor Applications in Zero Gravity
Agency: NASA
Contract: NAS2-03121
Award Amount: $69,998.00
 

Abstract:

Intelligent Optical Systems, Inc. proposes to develop a fluorescence detection based miniature multisensor probe and detection system to monitor cell nutrient parameters in zero gravity. The proposed sensor system can be integrated into NASA?s bioreactor hardware to enhance performance. Luminescent nano-particles will be used as fluorescent indicators to provide greater signal intensity and to reduce photo-degradation. The ultimate optical nutrients monitor will be capable of detecting and monitoring vital nutrient parameters such as pH, temperature, dissolved carbon dioxide, dissolved oxygen, and glucose. The device will provide a continuous, unmanned measurement of the bioreactor?s parameters. The optical monitor will require no reagent replacement and is projected to be capable of long term unattended real-time monitoring of cell culture media.In Phase I, we will demonstrate the feasibility and sensitivity of the optical monitoring device and the single source fluorescence system using buffers and cell culture media (lacto bacillus). In Phase II, we will construct and test a field deployable prototype monitor to be used in a NASA bioreactor project.

Principal Investigator:

Raghuvir Singh
Principal Investigator
3105307130
sbirproposals@intopsys.com

Business Contact:

Ashutosh Sharma
Business Official
3105307130
r&doffice@intopsys.com
Small Business Information at Submission:

Intelligent Optical Systems, Inc.
2520 W. 237th Street Torrance, CA 90505

EIN/Tax ID: 954680779
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No