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Development of a phage-based technology for eliminating or significantly…

Award Information

Department of Defense
Award ID:
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
351 W CAMDEN ST STE 100 Baltimore, MD 21201-8603
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2006
Title: Development of a phage-based technology for eliminating or significantly reducing contamination of fruits and vegetables with E. coli O157:H7
Agency / Branch: DOD / ARMY
Contract: W911QY-07-C-0009
Award Amount: $69,995.00


Foodborne illnesses of microbial origin continue to be serious food safety problems worldwide, and they also may substantively hamper military operations. Thus, the availability of approaches which significantly reduce contamination of foods with various bacterial pathogens is of paramount importance for ensuring the safety and operational readiness of US troops worldwide, as well as for the safety of civilian populations. Ready-to-eat-foods (RTEFs) are of particular concern because they are not subjected to cooking, which kills most bacteria. However, bacterial decontamination of RTEFs presents considerable challenges because the efficacy of currently available chemical food-sanitizers is imperfect, and many of them damage food quality and adversely affect the environment. Thus, novel, environmentally-safe and effective approaches are needed to ensure the safety of foods that may be intentionally (e.g., bioterrorism) or naturally contaminated with pathogenic bacteria. Bacteriophages, viruses that kill bacteria, may provide one such approach. Intralytix is one of the world's leading companies specializing in the development of phage preparations for improving food safety. Thus, in response to the US Army's request to develop phage technology effective against biological pathogens in foods, we propose to develop and test a lytic phage preparation ("EcoPhage") for reducing contamination of fruits and vegetables with E. coli O157:H7.

Principal Investigator:

Alexander Sulakvelidze
Chief Scientist

Business Contact:

John D. Vazzana
President and CEO
Small Business Information at Submission:

The Columbus Center, 701 East Pratt Street Baltimore, MD 21202

EIN/Tax ID: 522112466
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No