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Bacteriophage therapy for treating A. baumannii infected wounds
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 2009Title: Bacteriophage therapy for treating A. baumannii infected woundsAgency / Branch: DOD / DARPAContract: W81XWH-09-C-0164Award Amount: $99,991.00
Abstract:
Treatment of bacterial-infected wounds is one the most critical problems in modern medicine, and it presents one of the most significant challenges for US troops during combat operations. The management of bacteria in wounds is complicated by the existence of multidrug-resistant strains and mutants. Therefore, novel modalities for preventing and treating wound infections, one of which may be highly purified and characterized bacteriophage preparations, are required. Lytic phages (i.e., bacterial viruses that infect and lyse their specific bacterial hosts) have been used to treat bacterial infections since their discovery during the first decade of the 20th century. However, their therapeutic use gradually declined in the "Western World" after the advent of antibiotics. At the present time, there is renewed interest in phage-based prophylactic and therapeutic approaches because phages are active against multidrug-resistant, pathogenic bacterial strains and mutants. Our current application proposes to develop a potent lytic bacteriophage preparation/cocktail against A. baumannii - a major wound pathogen of particular concern to the US Army, and an increasingly important public health problem. In addition, we will develop two murine wound-infection models for future studies evaluating our A. baumannii phage cocktail's efficacy in treating A. baumannii wound infections.Small Business Information at Submission:Research Institution Information:Intralytix, Inc.
The Columbus Center 701 E. Pratt Street Baltimore, MD 21202EIN/Tax ID: 522112466DUNS: N/ANumber of Employees:Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: NoUniversity of Florida
Division of Sponsored Research
P.O. Box 115500
Gainesville, FL 32611 5500Contact: Brian PrindleContact Phone: (352) 392-3516RI Type: Nonprofit college or university
Award Information
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Agency: Department of Defense |
Branch: Defense Advanced Research Projects Agency |
Award ID: 90069 |
Program Year/Program: 2009 / STTR |
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Agency Tracking Number: A09A-026-0171 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |