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Company Information:

Company Name: INTRINSIC BIOPROBES, INC.
City: TEMPE
State: AZ
Zip+4: 85284-2604
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,689,527.00 17
SBIR Phase II $7,097,258.00 11
STTR Phase I $738,777.00 1
STTR Phase II $1,266,916.00 1

Award List:

BIOSENSOR CHIP MASS SPECTROMETRY

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nelson, Randall W
Award Amount: $106,906.00

BIOREACTIVE MASS SPECTROMETER PROBES

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Nelson, Randall W
Award Amount: $99,820.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Nelson Randall W
Award Amount: $1,034,835.00

MASS SPECTROMETRY BASED QUANTITATIVE ASSAYS

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $106,131.00
Abstract:
Not Available This proposed Phase I effort is directed towards development of a new speckle position displacement sensor to be used as a navigation sensor for military operations in an urban environment in areas where GPS signals are not available (e.g., buildings, tunnels, forested areas and high… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $245,463.00

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,360.00

N/A

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $96,150.00

MASS SPECTROMETRY BASED HIGH THROUGHPUT PROTEOMICS APPROACH

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $99,377.00

BIOSENSOR-CHIP MASS SPECTROMETRY

Award Year / Program / Phase: 2002 / SBIR / Phase II
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $688,540.00
Abstract:
Biosensor Chip Mass Spectrometry (BCMS) is an arrayed, chip-based platform intended for use in the rigorous investigation of trace-level proteins present in complex biological mixtures. BCMS may be used as a protein-based complement to genotyping approaches for SNP analysis, or even used on its own… More

BIOSENSOR-CHIP MASS SPECTROMETRY

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $0.00
Abstract:
Biosensor Chip Mass Spectrometry (BCMS) is an arrayed, chip-based platform intended for use in the rigorous investigation of trace-level proteins present in complex biological mixtures. BCMS may be used as a protein-based complement to genotyping approaches for SNP analysis, or even used on its own… More

Affinity-based Mass Spectrometry Protein Assays

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dobrin Nedelkov
Award Amount: $129,319.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this Phase I - Phase II Fast Track Research Proposal is to advance the development of a combined Mass Spectrometric Immunoassay (MSIA) - Bioreactive Mass Spectrometer Probes (BRP) approach to a robust multiplexed technology that will ultimately… More

Affinity-based Mass Spectrometry Protein Assays

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Dobrin Nedelkov
Award Amount: $1,482,920.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this Phase I - Phase II Fast Track Research Proposal is to advance the development of a combined Mass Spectrometric Immunoassay (MSIA) - Bioreactive Mass Spectrometer Probes (BRP) approach to a robust multiplexed technology that will ultimately… More

Mass Spectrometric Immunoassay of Apolipoproteins

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $111,948.00
Abstract:
DESCRIPTION (provided by applicant): Proposed in this Fast Track Phase I/Phase II proposal is the development of mass spectrometric immunoassays (MSIA) targeting apolipoproteins in human blood. Assays, utilizing antibody-derivatized affinity pipettes and MALDI-TOF mass spectrometry, will be… More

Mass Spectrometric Immunoassay of Apolipoproteins

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $1,029,846.00
Abstract:
DESCRIPTION (provided by applicant): Proposed in this Fast Track Phase I/Phase II proposal is the development of mass spectrometric immunoassays (MSIA) targeting apolipoproteins in human blood. Assays, utilizing antibody-derivatized affinity pipettes and MALDI-TOF mass spectrometry, will be… More

N/A

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $181,137.00

MASS SPECTROMETRY BASED HIGH THROUGH PUT PROTEOMICS APPROACH

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $0.00

MASS SPECTROMETRY BASED HIGH THROUGH PUT PROTEOMICS APPROACH

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $477,552.00

Mass Spectrometry Assays for Biodefense Agents

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Randall W. Nelson
Award Amount: $295,015.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this Phase I Research Proposal is to develop affinity-based mass spectrometry assay for detection of the NIAID High Priority Biodefense Agent Staphylococcal Enterotoxin B (SEB). The assay will utilize affinity capture in pipette-fitted… More

MS based approaches for diabetes biomarker discovery

Award Year / Program / Phase: 2005 / STTR / Phase I
Agency: HHS
Research Institution: YALE UNIVERSITY
Principal Investigator: Urban A. Kiernan
Award Amount: $738,777.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): The objective of this proposal is to apply novel affinity mass spectrometry (AMS) technologies to identify protein biomarkers for pre-diabetes or type 2 diabetes. The methodology used combines micro-affinity protein capture from complex biological solutions with… More

SBIR Phase I: Proteomic-Based Detection Technology

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: NSF
Principal Investigator: Dobrin Nedelkov, Dr
Award Amount: $91,562.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project will develop proteomic-based security technology that will incorporate affinity-based mass spectrometry assays and software for the detection of Biodefense Agents. Existing immunoassay methods for proteomic detection of specific… More

MASS SPECTROMETRY BASED HIGH THROUGH PUT PROTEOMICS APPROACH

Award Year / Program / Phase: 2005 / SBIR / Phase II
Agency: HHS
Principal Investigator: Randall Nelson
Award Amount: $116,089.00

Mass Spectrometry Assays for Biodefense

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: HHS
Principal Investigator: Eric E. Niederkofler
Award Amount: $693,162.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this Phase II Research Proposal is to continue the successfully completed work of the Phase I Research project by further developing affinity-based mass spectrometry assays for the detection/characterization of Biodefense agents, specifically the… More

Discovery of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Urban A. Kiernan
Award Amount: $109,460.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this proposal is to apply novel affinity mass spectrometry (AMS) technologies to identify protein biomarker fingerprints indicative of alcohol consumption. The methodology used combines micro-affinity protein capture from complex biological… More

MS based approaches for diabetes biomarker discovery

Award Year / Program / Phase: 2007 / STTR / Phase II
Agency: HHS
Research Institution: N/A
Principal Investigator: Urban A. Kiernan
Award Amount: $1,266,916.00
RI Contact: N/A
Abstract:
DESCRIPTION (provided by applicant): The objective of this proposal is to apply novel affinity mass spectrometry (AMS) technologies to identify protein biomarkers for pre-diabetes or type 2 diabetes. The methodology used combines micro-affinity protein cap ture from complex biological solutions with… More

SBIR TOPIC 254 - MULTIPLEX MASS SPECTROMETRIC IMMUNOASSAYS

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dobrin Nedelkov
Award Amount: $147,160.00
Abstract:
The objective of the Phase II research project is to continue the development of a quantitative, automated, high throughput, multiplex affinity protein capture technology platform and multiplex mass spectrometric immunoassays for the analysis of more than 50 cancer-related peptides and proteins from… More

Validation of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Urban A. Kiernan
Award Amount: $774,416.00
Abstract:
DESCRIPTION (provided by applicant): The objective of this proposal is to validate potential biomarkers of excessive alcohol exposure discovered in the Phase 1 portion of this work (1R43AA016233-01). This will entail the development of pipettor tip based i mmuno-affinity mass spectrometry (AMS)… More

Quantitative Mass Spectrometric Immunoassays for Population Proteomics

Award Year / Program / Phase: 2009 / SBIR / Phase I
Agency: HHS
Principal Investigator: Dobrin Nedelkov
Award Amount: $197,319.00
Abstract:
DESCRIPTION (provided by applicant): The main objective of this Phase I project is to develop quantitative Mass Spectrometric Immunoassays for beta-2-microglobulin, cystatin C, transferrin, transthyretin, and retinol binding protein. These five proteins we re recently assayed via qualitative mass… More

TAS::75 0849::TAS OPTION EXERCISE MODIFICATION

Award Year / Program / Phase: 2011 / SBIR / Phase II
Agency: HHS
Principal Investigator: Kemmons Tubbs – 480-804-1778
Award Amount: $373,298.00
Abstract:
This proposal sets forth a precise and rapid methodology for identifying the interaction sites between monoclonal antibodies and proteins. The basis of the system is a high-throughput mass spectrometry-based analysis of epitope determinants to identify theinteracting protein sequences using… More