You are here

BIOSENSOR-CHIP MASS SPECTROMETRY

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44CA082079-03A1
Agency Tracking Number: CA082079
Amount: $688,540.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
INTRINSIC BIOPROBES, INC. 625 S SMITH RD, STE 22
TEMPE, AZ 85281
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RANDALL NELSON
 (408) 804-1778
 RNELSON@INTRINSICBIO.COM
Business Contact
 KEMMONS TUBBS
Phone: (480) 804-1778
Email: KTUBBS@INTERINSICBIO.COM
Research Institution
N/A
Abstract

Biosensor Chip Mass Spectrometry (BCMS) is an arrayed, chip-based platform intended for use in the rigorous investigation of trace-level proteins present in complex biological mixtures. BCMS may be used as a protein-based complement to genotyping approaches for SNP analysis, or even used on its own in phenotyping or clinical studies. The overall goal of this project is to further evaluate and validate the use of BCMS in important biological applications. Several selected proteins will be used as test systems and analyzed via BCMS. When perfected, BCMS will become a true chip-based proteomics tool with integrated sample preparation components, capable of rapid in-vitro analysis. As such, it stands to be employed in a variety of applications, such as identifications of molecular markers, identification and characterization of protein interactions, examination of molecular basis and profiles of a variety of ailments and delineation of protein structure/function in general. PROPOSED COMMERCIAL APPLICATIONS: Biosensor Chip Mass Spectrometry represents what we believe to be the first "lab-on-a-chip" concerted, multiplexed approach capable of protein fractionation, processing and structural analysis of proteins present in biological fluids at low levels. The routine use of BCMS will contribute to a limitless number of investigations, ranging from screening of biological markers and protein profiling to assaying protein-protein interactions.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government