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Validation of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
80248 		Program Year/Program:
2009 / SBIR
Agency Tracking Number:
AA016223 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
INTRINSIC BIOPROBES, INC.
2155 E CONFERENCE DR STE 104 TEMPE, AZ 85284-2604
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2009
Title: Validation of Alcohol Exposure Biomarkers via Affinity Mass Spectrometry
Agency: HHS
Contract: 2R44AA016223-02
Award Amount: $774,416.00
 

Abstract:

DESCRIPTION (provided by applicant): The objective of this proposal is to validate potential biomarkers of excessive alcohol exposure discovered in the Phase 1 portion of this work (1R43AA016233-01). This will entail the development of pipettor tip based i mmuno-affinity mass spectrometry (AMS) devices for the routine and repetitive high throughput analysis of the biomarkers in question. Resultant devices will allow for both quantitative and qualitative differentiation of the markers of interest. With the su ccessful development of immuno-AMS devices for the biomarkers in question, they will be used to screen clinical samples collected by our clinical collaborators (Aurora Psychiatric Hospital, Wauwatosa, WI) in order to validate their performance. Final metri cs for the evaluation of the biomarker assays developed will be a clinical sensitivity and specificity of 85%, with coefficients of variation of lt15%. PUBLIC HEALTH RELEVANCE: Alcohol abuse has a significant impact on our society, yet there are no accurat e biomarker tests for prognostic, diagnostic or treatment efficacy assessment currently available. This application is to validate new biomarkers of excessive alcohol exposure using a novel in pipettor tip immuno-affinity mass spectrometry based assay. Cle arly, accurate and specific biomolecular assays are of great importance, positively impacting the associated health, financial and emotional repercussions of alcohol abuse.

Principal Investigator:

Urban A. Kiernan
4808041778
UKIERNAN@INTRINSICBIO.COM

Business Contact:

Austin U. Kiernan
info@intrinsicbio.com
Small Business Information at Submission:

INTRINSIC BIOPROBES, INC.
INTRINSIC BIOPROBES, INC. 2155 E. Conference Dr. Suite 104 TEMPE, AZ 85284

EIN/Tax ID: 860842933
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No