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PARATHYROID IMAGING BY RADIOLABELED MONOCLONAL ANTIBODY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4745
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
4745
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Invitron Corp
4649 Le Bourget Dr Saint Louis, MO 63134
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: PARATHYROID IMAGING BY RADIOLABELED MONOCLONAL ANTIBODY
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE GOAL OF THIS PROJECT IS TO DEVELOP A MONOCLONAL ANTIBODY-BASED IMAGING REAGENT CAPABLE VISUALIZING HUMAN PARATHYROIDGLANDS. THE STUDY WILL BE DIRECTED AT ISOLATION AND CHARACTERIZATION OF HUMAN PARATHYROID-SPECIFIC MOUSE MONOCLONAL ANTIBODIES AND PRELIMINARY ANALYSIS OF THEIR TARGET ANTIGENS. AS THE CLASS AND SUBCLASS OF ANTIBODIES WILL LIKELY INFLUENCE IMAGING PROPERTIES, VARIANTS OF HYBRIDOMAS WILL BE SELECTED BY FLUORESCENCE-ACTIVATED CELL SORTERS THAT SECRETE IMMUNOGLOBULINS OF DIFFERENT IGG SUBCLASSES AND IGM. THESE ANTIBODIES WILL BE TESTED FOR LOCALIZATION OF HUMAN PARATHYROID FRAGMENTS IN NUDE MICE. FUTURE PHASE II STUDIES WILL FOCUS ON THE IMAGING PARAMETERSOF THESE VARIANT ANTIBODIES IN LARGE ANIMALS, SUCH AS DOGS OR MONKEYS, TO SELECT THE OPTIMAL CONDITIONS FOR IMAGING IN HUMANS.

Principal Investigator:

Charles Benton
Principal Investigator
3147278255

Business Contact:

Small Business Information at Submission:

Invitron Corp.
4649 Le Bourget Dr St Louis, MO 63134

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No