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Company Information:

Company Name:
IONWERKS, INC.
Address:
3401 Louisiana St., Suite 355
HOUSTON, TX
Phone:
(713) 522-9880
URL:
N/A
EIN:
176058969
DUNS:
154074553
Number of Employees:
11
Woman-Owned?:
No
Minority-Owned?:
No
HUBZone-Owned?:
No

Commercialization:

Has been acquired/merged with?:
N/A
Has had Spin-off?:
N/A
Has Had IPO?:
N/A
Year of IPO:
N/A
Has Patents?:
N/A
Number of Patents:
N/A
Total Sales to Date $:
$ 0.00
Total Investment to Date $
$ 0.00
POC Title:
N/A
POC Name:
N/A
POC Phone:
N/A
POC Email:
N/A
Narrative:
N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $3,766,859.00 46
SBIR Phase II $12,762,098.00 15
STTR Phase I $199,882.00 2
STTR Phase II $749,856.00 1

Award List:

ANALYSIS OF LI, H, AND D ON FUSION MATERIALS

Award Year / Program / Phase:
1986 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
DOE
Principal Investigator:
Dr. j. albert schultz , PRINCIPAL INVESTIGATOR
Abstract:
Determination of the elemental composition of the outermost layer of alloys is crucial for the design of self-sustainingcoatings for the first wall materials in a fusion reactor. direct recoil spectroscopy (drs) overcomes the limitations inherent in all other surface analytical approaches for the… More

IMPURITY CONCENTRATIONS ON GAAS(100)

Award Year / Program / Phase:
1986 / SBIR / Phase I
Award Amount:
$50,000.00
Agency / Branch:
DOD / DARPA
Principal Investigator:
J albert schultz
Abstract:
Determination of the surface stoichiometry of semiconductor surfaces during processing by mbe or cvd is desireable. direct recoil spectroscopy (drs) may overcome the limitations inherent in conventional surface analysis so that analysis of gaas surfaces simultaneously for h, c, o, n, al, si, fe, zn,… More

APPLICATION OF VLSI TO VECTOR ACCUMULATORS AND INTEGRATING TIME TO DIGITAL CONVERTER

Award Year / Program / Phase:
1987 / SBIR / Phase I
Award Amount:
$49,968.00
Agency / Branch:
DOD / DARPA
Principal Investigator:
Dr fhoward k schmidt
Abstract:
Design, simulation, fabrication, and evaluation of a prototype very large scale integration (vlsi) data acquisition subsystem is proposed. available state-of-the-art one micron cmos technology may allow incorporation of more than 128 channels of 24-bit 300 mhz counters into a single integrated… More

AN IN-SITU URANIUM ISOTOPE MEASUREMENT FOR USE IN ATOMIC VAPOR LASER ISOTOPE SEPARATION

Award Year / Program / Phase:
1988 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
DOE
Principal Investigator:
Abstract:
An instrument is under development that will quantitatively measure isotopic ratios on a solid or liquid surface of uranium (or other elements). the instrument uses a pulsed ion beam at grazing incidence to knock surface atoms off in billiard ball type collisions. some of these atoms are ionized and… More

INSTRUMENTATION FOR HIGH RESOLUTION ELECTRON LOSS SPECTROSCOPY FOR VIBRATIONAL ANALYSIS OF ROUGH PRACTICAL SURFACES

Award Year / Program / Phase:
1988 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
NSF
Principal Investigator:
J albert schultz phd
Abstract:
Electron loss spectroscopy for vibrational analysis is an established technique best suited for adsorbates on polishedmetallic surfaces. ionwerks proposes a departure from the standard instrumentation which allow vibrational measurements on practical surfaces such as rough metallic oxides. our… More

SYNTHESIS IN HIGH T(C) SUPERCONDUCTORS REQUIRING NO POST-ANNEAL

Award Year / Program / Phase:
1988 / SBIR / Phase I
Award Amount:
$50,000.00
Agency / Branch:
DOD / USAF
Principal Investigator:
J albert schultz
Abstract:
We will explore the possibility of fabricating superconductor material using low energy ion beam techniques. the goal will be both to improve the epitaxial growth of superconductor thin films on substrates and to remove the necessity of harsh post-annealling in oxygen ambients.

ATOMIC OXYGEN SOURCE FOR SUPERCONDUCTOR THIN FILM FABRICATION

Award Year / Program / Phase:
1989 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
NASA
Principal Investigator:
J Albert Schultz Ph D
Abstract:
We will explore the possibility of fabricating superconductor material using a low energy high flux atomic oxygen source. the goal will be both to improve the epitaxial growth of superconductor thin films on substrates and to remove the necessity of harsh post-annealling in oxygen ambients.

A TECHNIQUE FOR MEASURING DIFFUSION OF HYDROGEN ISOTOPES IN OXIDES

Award Year / Program / Phase:
1990 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
DOE
Principal Investigator:
Abstract:
Surface metal oxide and oxyhydroxide layers have been implicated as tritium traps in stainless steels. a new technique is being developed for measuring hydrogen isotope diffusion within this layer and within permeation barriers meant to limit tritium inventory in these materials.

MONITORING/MODIFYING THIN FILM GROWTH

Award Year / Program / Phase:
1990 / SBIR / Phase I
Award Amount:
$50,000.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J Albert Schultz
Abstract:
N/a

MASS SPECTROSCOPY OF RECOILED IONS (MSRI FOR U-PB GEOCHRONOLOGY

Award Year / Program / Phase:
1991 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
NSF
Principal Investigator:
J. Albert Schultz , Owner
Abstract:
A new technique is being developed for minority isotope and trace element analysis on solid surfaces. the apparatus is simple, reliable, and relatively inexpensive. direct recoiling of surface atoms results in complete reduction to elemental ions. molecular isobaric interferences are eliminated… More

MONITORING/MODIFYING THIN FILM GROWTH

Award Year / Program / Phase:
1991 / SBIR / Phase II
Award Amount:
$489,000.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J Albert Schultz
Abstract:
N/a

TECHNIQUE FOR IN-SITU QUANTITATION OF DOPANTS AND MAJOR ELEMENT DURING EPILAYER GROWTH AND PROCESSING

Award Year / Program / Phase:
1991 / SBIR / Phase I
Award Amount:
$50,000.00
Agency / Branch:
DOD / ARMY
Principal Investigator:
J Albert Schultz , Principal Investigator
Abstract:
N/a

IN SITU SURFACE ELEMENTAL ANALYSIS/PROCESS CONTROL AT MILLITORR PRESSURE DURING SUPERCONDUCTOR FILM DEPOSITION

Award Year / Program / Phase:
1992 / SBIR / Phase I
Award Amount:
$50,000.00
Agency:
DOE
Principal Investigator:
Abstract:
The high pressure limits of a new proprietary technique for surface elemental and isotopic analysis are being explored. the technique should be useful in the millitorr pressure regime, thus allowing measurement of thin film stoichiometry during growth and processing. the present research is focusing… More

Monitoring Epitaxial Layer Growth

Award Year / Program / Phase:
1992 / SBIR / Phase I
Award Amount:
$49,283.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J. Albert Schultz
Abstract:
N/a

TECHNIQUE FOR IN-SITU QUANTITATION OF DOPANTS AND MAJOR ELEMENT DURING EPILAYER GROWTH AND PROCESSING

Award Year / Program / Phase:
1993 / SBIR / Phase II
Award Amount:
$499,094.00
Agency / Branch:
DOD / ARMY
Principal Investigator:
J Albert Schultz , Principal Investigator
Abstract:
A technique will be demonstrated which can provide accurate and quantia technique will be demonstrated which can provide accurate and quantitative elemental analysis in real time during epilayer growth and proctative elemental analysis in real time during epilayer growth and processing. the… More

Monitoring Epitaxial Layer Growth

Award Year / Program / Phase:
1993 / SBIR / Phase II
Award Amount:
$200,000.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J. Albert Schultz
Abstract:
When making a structure like AlGaAs or SiGe by heteroexpitaxial growth techniques, it would be nice to know when one atomic layer is completed so that the next can be started. The quality of the device depends on accurate control of the thickness and purity of each layer. Currently, no way exists to… More

LARGE AREA NON-CONTAMINATING HIGH FLUX ATOMIC HYDROGEN SOURCE

Award Year / Program / Phase:
1994 / SBIR / Phase I
Award Amount:
$59,558.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J. Albert Schultz
Abstract:
A new approach to generating atomic hydrogen (and possibly N and O) will give atomic fluxes of 10(-19) atoms/cm(-2) over a three inch wafer positioned three inches in front of the source. Scalt up to larger areas may be possible in phase II. We will examine the use of this source as an alternative… More

GROWTH OF LATTICE MATCHED GAN/INGAN/ZNO IN A MBE/CBE CHAMBER OPTIMIZED FOR HIGH TEMPERATURE WIDE BANDGAP NITRIDE GROWTH

Award Year / Program / Phase:
1994 / SBIR / Phase I
Award Amount:
$60,000.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J. Albert Schultz
Abstract:
Ionwerks has begun an internally funded project to design and manufacture an MBE growth chamber specifically designed and optimized for wide bandgap nitrides (compatible with Si/Ge growth also). This chamber will include two proprietary growth techniques which we have found to be crucial for… More

ATOMIC LAYER EPITAXY DEPOSITION OF N AND P DOPED CUBIC BORON NITRIDE THIN FILMS FOR HIGH TEMPERATURE SEMICONDUCTING DEVICES

Award Year / Program / Phase:
1994 / SBIR / Phase I
Award Amount:
$65,000.00
Agency:
NSF
Principal Investigator:
Kelley L Waters
Abstract:
Understanding the behavior on n- and p-type doped cubic boron nitride (cbn) thin films is important to the ability to make electronic devices to take advantage of the thermal as well as electronic properties of cbn. n- and p-type doped cbn are being grown using atomic layer epitaxy (ale) in a… More

MBE Thin Film Formation Using Nitrogen Source

Award Year / Program / Phase:
1995 / SBIR / Phase I
Award Amount:
$59,953.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J. Albert Schultz
Abstract:
A novel nitrogen beam source will provide 5 eV atomic and molecular nitrogen to a 0.5 cm diameter circle with a flux of 10(21)/cm(2)/sec. Larger areas can be irradiated with a lower flux (eg. 10(18)/cm(2)/sec over a 2" diameter wafer). The technique will put minimal gas load into the chamber so it… More

Cryo-Radical Chemistry and Cluster Beam Deposition

Award Year / Program / Phase:
1995 / SBIR / Phase I
Award Amount:
$59,546.00
Agency / Branch:
DOD / MDA
Principal Investigator:
J. Albert Schultz
Abstract:
A unique approach to formation of nitride materials using matrix isolation methods will be attempted. Large quantities of reactants can be prepared and forced to react under much more controlled conditions than in CVD or MBE. Important issues that will be addressed are epitaxial growth and growth… More

HIGH FLUX ATOMIC OXYGEN SOURCE ALLOWING RAPID OXIDE THIN FILM GROWTH IN LOW EARTH ORBIT

Award Year / Program / Phase:
1996 / SBIR / Phase I
Award Amount:
$68,011.00
Agency:
NASA
Principal Investigator:
J. Albert Schultz , Owner
Abstract:
N/a

Novel Pulsed Nitrogen Source Diagnostic for GaN Thin Film Stoichiometry Control

Award Year / Program / Phase:
1996 / SBIR / Phase I
Award Amount:
$100,000.00
Agency / Branch:
DOD / USAF
Principal Investigator:
J. Albert Schultz
Abstract:
N/a

Novel Pulsed Nitrogen Source Diagnostic for GaN Thin Film Stoichiometry Control

Award Year / Program / Phase:
1997 / SBIR / Phase II
Award Amount:
$732,936.00
Agency / Branch:
DOD / USAF
Principal Investigator:
J. Albert Schultz
Abstract:
Good insitu tools exist for measuring temperatures and thickness during epitaxial thin film growth. In contrast, almost no technique gives information on surface elemental composition in real time. We propose an extremely simple experiment which can be performed with an ion source little… More

HIGH FLUX ATOMIC OXYGEN SOURCE ALLOWING RAPID OXIDE THIN FILM GROWTH IN LOW EARTH ORBIT

Award Year / Program / Phase:
1997 / SBIR / Phase II
Award Amount:
$598,675.00
Agency:
NASA
Principal Investigator:
J. Albert Schultz , Owner
Abstract:
N/a

A Flight Rated Time Of Flight Mass Spectrometer With 10(-15) Torr Sensitivity For Insitu Thin Film Process Control

Award Year / Program / Phase:
1997 / SBIR / Phase I
Award Amount:
$70,000.00
Agency:
NASA
Principal Investigator:
J. Albert Schultz , OWNER
Abstract:
N/a

ULTRA SENSITIVE MULTIHIT ION DETECTOR--TOF BIOMASSPEC

Award Year / Program / Phase:
1997 / SBIR / Phase I
Award Amount:
$98,880.00
Agency:
HHS
Principal Investigator:
Schultz, j albert
Abstract:
N/a

HIGH MASS RESOLUTION FOR MALDI TOF MASS SPECTROMETRY

Award Year / Program / Phase:
1998 / SBIR / Phase I
Award Amount:
$99,949.00
Agency:
HHS
Principal Investigator:
Schultz, J A
Abstract:
N/a

A Flight Rated Time Of Flight Mass Spectrometer With 10(-15) Torr Sensitivity For Insitu Thin Film Process Control

Award Year / Program / Phase:
1998 / SBIR / Phase II
Award Amount:
$588,236.00
Agency:
NASA
Principal Investigator:
J. Albert Schultz , OWNER
Abstract:
N/a

A New Instrument for SIMS sputter depth profiling of Semiconductor Heterostructures and Shallow Junction Implants

Award Year / Program / Phase:
1999 / SBIR / Phase I
Award Amount:
$99,934.00
Agency / Branch:
DOD / USAF
Principal Investigator:
Katrin Fuhrer
Abstract:
N/a

DETECTORS FOR LARGE BIOMOLECULAR IONS

Award Year / Program / Phase:
1999 / SBIR / Phase I
Award Amount:
$99,458.00
Agency:
HHS
Principal Investigator:
Katrin Fuhrer
Abstract:
N/a

Nitride-based Cold Cathodes for Minature and Rugged Electron Sources

Award Year / Program / Phase:
1999 / SBIR / Phase I
Award Amount:
$99,877.00
Agency:
DOE
Principal Investigator:
Abstract:
Not Available Maximizing the use of available frequency spectrum is crucial for both military and commercial systems today. The class of waveforms called Continuous Phase Modulation (CPM) signaling, with Gaussian Minimum Shift Keying (GMSK) as a specific instantiation, have been shown to be highly… More

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$99,854.00
Agency:
HHS
Principal Investigator:
Abdelhakim A. Bensaoula
Abstract:
Not Available ITN proposes a new, innovative material system and rigidizing approach for self-rigidizing inflatable space structures, comprising: graphite fiber/thermoplastic matrix composite (Gr/TP) material with an inflatable inner bladder and an outer restraining sk

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$70,000.00
Agency:
NASA
Principal Investigator:
Katrin Fuhrer, Research Scientist
Abstract:
N/a

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
Katrin Fuhrer
Abstract:
N/a

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase II
Award Amount:
$266,850.00
Agency:
HHS
Principal Investigator:
Katrin Fuhrer
Abstract:
N/a

N/A

Award Year / Program / Phase:
2000 / SBIR / Phase I
Award Amount:
$99,858.00
Agency:
NSF
Principal Investigator:
Abdelhakim Bensaoula
Abstract:
N/a

High Mass Resolution for MALDI TOF Mass Spectrometry

Award Year / Program / Phase:
2001 / SBIR / Phase I
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
J. A. Schultz
Abstract:
N/a

High Mass Resolution for MALDI TOF Mass Spectrometry

Award Year / Program / Phase:
2001 / SBIR / Phase II
Award Amount:
$451,717.00
Agency:
HHS
Principal Investigator:
J. A. Schultz
Abstract:
N/a

Filamentless Molecular Beam Ionizer for Time-of-Flight Mass Spectrometry

Award Year / Program / Phase:
2001 / SBIR / Phase II
Award Amount:
$600,000.00
Agency:
NASA
Principal Investigator:
Katrin Fuhrer, Research Scientist
Abstract:
Recent innovations in diamond and boron nitride field emissive thin film fabrication have yielded materials which may be suitable as replacements for hot filament electron ionizers for mass spectrometers. Our phase I effort will be to fabricate an innovative ionizer structure and implement it in our… More

Filamentless Molecular Beam Ionizer for Time-of-Flight Mass Spectrometry

Award Year / Program / Phase:
2001 / SBIR / Phase I
Award Amount:
$0.00
Agency:
NASA
Principal Investigator:
Katrin Fuhrer, Research Scientist
Abstract:
Recent innovations in diamond and boron nitride field emissive thin film fabrication have yielded materials which may be suitable as replacements for hot filament electron ionizers for mass spectrometers. Our phase I effort will be to fabricate an innovative ionizer structure and implement it in our… More

N/A

Award Year / Program / Phase:
2001 / SBIR / Phase I
Award Amount:
$99,647.00
Agency:
NSF
Principal Investigator:
Abstract:
This Small Business Innovation Research Phase I (SBIR) project will test Cesium Iodide cluster ion beams as an alternative to lasers for desorbing bioions from a MALDI ((Matrix Assisted Laser Desorption Ionization) matrix. This offers the possiblity of performing the post source decay tandem mass… More

DRUG/RECEPTOR CONFORMATION BY ELECTROSPRAY-MOBILITY-MS

Award Year / Program / Phase:
2002 / SBIR / Phase I
Award Amount:
$99,614.00
Agency:
HHS
Principal Investigator:
Thomas F. Egan
Abstract:
N/a

Hybrid Data System and Ion Detector for TOF Mass Spectrometry

Award Year / Program / Phase:
2003 / SBIR / Phase I
Award Amount:
$69,983.00
Agency:
NASA
Principal Investigator:
William Burton, Principal Investigator
Abstract:
Previous phase II work has resulted in a compact Time-of-Flight mass spectrometer developed for sensitive detection of hydrogen and oxygen leaks prior to and during the few seconds after engine start and before launch of the space shuttle. The main challenges for this application--sensitivity,… More

Characterization and synthesis of carbon nano-materials by LDI-IM TOF MS

Award Year / Program / Phase:
2003 / SBIR / Phase I
Award Amount:
$69,856.00
Agency:
NASA
Principal Investigator:
Michael Ugarov, Principal Investigator
Abstract:
This Small Business Innovation Research Phase I project addresses problems of the synthesis and separation of carbon nanotubes for a wide range of nanotechnology applications. We propose to use unique capabilities of Laser Desorption Ionization - Ion Mobility Time-of-Flight Mass Spectrometry for… More

Photofragmentation MS of Ion Mobility Separated Peptides

Award Year / Program / Phase:
2003 / SBIR / Phase I
Award Amount:
$99,459.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project proposal is focused on the development of a commercial instrument capable of rapid, high-throughput identification of peptides based on matrix-assisted laser desorption ionization, ion mobility spectrometry,… More

N/A

Award Year / Program / Phase:
2003 / SBIR / Phase I
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
J. A. Schultz
Abstract:
N/a

N/A

Award Year / Program / Phase:
2003 / SBIR / Phase II
Award Amount:
$749,143.00
Agency:
HHS
Principal Investigator:
J. A. Schultz
Abstract:
N/a

N/A

Award Year / Program / Phase:
2003 / SBIR / Phase I
Award Amount:
$99,644.00
Agency:
HHS
Principal Investigator:
J. A. Schultz
Abstract:
N/a

Infrared Laser Desorption Ion Mobility Mass Spectrometer

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$99,944.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): The goal of this research program is to develop an infrared laser desorption ionization (IR-LDI ion mobility mass spectrometer (IMMS) for application to the analysis of biomolecules in complex systems such as direct tissue studies and the identification of the… More

NEW APPROACH TO PROTEOMICS

Award Year / Program / Phase:
2004 / SBIR / Phase I
Award Amount:
$0.00
Agency:
HHS
Principal Investigator:
Albert Schultz
Abstract:
N/a

NEW APPROACH TO PROTEOMICS

Award Year / Program / Phase:
2004 / SBIR / Phase II
Award Amount:
$900,532.00
Agency:
HHS
Principal Investigator:
Albert Schultz
Abstract:
N/a

Photofragmentation MS of Ion Mobility Separated Peptides

Award Year / Program / Phase:
2005 / SBIR / Phase II
Award Amount:
$749,954.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): Ion mobility (IM) is a perfect instrumental platform for slowing and separating peptide ions-this innovation has enabled efficient VUV photofragmentation (IM-oTOFMS/MS) to be demonstrated in phase I. VUV photofragmentation yields a near perfect technology for "on… More

Real-time monitoring of SWNT nucleation and growth in laser oven reactor

Award Year / Program / Phase:
2005 / STTR / Phase I
Award Amount:
$99,903.00
Agency / Branch:
DOD / USAF
Principal Investigator:
J. A. Schultz, President/Director of Research
Research Institution:
RICE UNIV.
RI Contact:
Robert H. Hauge
Abstract:
An innovative and highly patented Ion Mobility orthogonal Time of Flight Mass Spectrometer (IM-oTOF MS) will characterize SWNT (single wall nanotube) growth in a laser oven reactor. Time evolution of the size distributions of carbon and metal catalyst cluster growth (either free or attached to… More

Real-time monitoring of SWNT nucleation and growth in laser oven reactor

Award Year / Program / Phase:
2006 / STTR / Phase II
Award Amount:
$749,856.00
Agency / Branch:
DOD / USAF
Principal Investigator:
J. A. Schultz, President
Research Institution:
RICE UNIV.
RI Contact:
Robert Hauge
Abstract:
In Phase I we have demonstrated the detection and identification of products of carbon single wall nanotubes (SWNT) synthesis by the laser oven growth process using our unique method of Ion Mobility orthogonal Time-of-Flight Mass Spectrometry (IM oTOF MS). The Phase II will be aimed at the… More

Rapid Detection of Gas Hazards and Leaks with an Atmospheric Sampling, High Resolution, Mass Spectrometer with Low Pumping Requirements

Award Year / Program / Phase:
2006 / SBIR / Phase I
Award Amount:
$69,774.00
Agency:
NASA
Principal Investigator:
J. Albert Schultz, Principal Investigator
Abstract:
Miniaturization of mass spectrometers is restricted almost exclusively by the ability of small vacuum pumps to remove gas loads during operation of the instrument. Our answer to this dilemma is a specialized interface that focuses a parallel beam of ionized gas molecules through an orifice that is… More

Infrared Laser Desorption Ion Mobility Mass Spectrometer

Award Year / Program / Phase:
2007 / SBIR / Phase II
Award Amount:
$594,039.00
Agency:
HHS
Principal Investigator:
Abstract:
DESCRIPTION (provided by applicant): The development of an infrared laser desorption ionization ion mobility mass spectrometer (IR LDI IM MS) will be continued. The analysis of test biomolecules such as peptides and proteins in the Phase I of the project h as demonstrated that the new system's… More

METHOD FOR MOLECULAR PROFILING OF TISSUES USING MALDI

Award Year / Program / Phase:
2007 / SBIR / Phase I
Award Amount:
$749,965.00
Agency:
HHS
Principal Investigator:
Albert J
Abstract:
N/a

USE OF IM CROSS-SECTION AND M/Z AS A UNIQUE IDENTIFIER OF LIPIDS and NEUROPEPTIDES

Award Year / Program / Phase:
2008 / SBIR / Phase I
Award Amount:
$99,983.00
Agency:
HHS
Principal Investigator:
Thomas F. Egan
Abstract:
The magnitude and dynamic range of data being generated by the NIDA MALDI-IM-o-TOFMS molecular imaging spectrometer demands a new approach to bioinfomatics. We are now able to record the spatial location of most molecules on the surface of bio-sample and a re attempting to develop techniques which… More

SBIR Phase I: A Detector for Co-Axial Micro-focused Ion Beams for Detection of Backscattered Ions and Secondary Electrons from semi-conducting surfaces

Award Year / Program / Phase:
2009 / SBIR / Phase I
Award Amount:
$99,949.00
Agency:
NSF
Principal Investigator:
Abstract:
This Small Business Innovation Research Phase I project is to develop a secondary electron detector which can be co-axially mounted with a micro-focused ion beam. Backscattered neutral atoms (and ions) and secondary electrons will be analyzed to give a measure both of surface element location and… More

Plasmon-Enhanced Laser Desorption Ionization

Award Year / Program / Phase:
2010 / STTR / Phase I
Award Amount:
$99,979.00
Agency / Branch:
DOD / USAF
Principal Investigator:
Ernest K. Lewis, Senior Research Scientist
Research Institution:
RICE UNIVERSITY
RI Contact:
Dr..Robert Hauge
Abstract:
Surface analysis of many classes of large polymers (e.g. non-polar synthetic polymer) by laser desorption mass spectrometry (LDMS) is not possible using existing MALDI matrices. Here, we uniquely address this problem by combining two recent proprietary commercial products available exclusively from… More

Microfocused Nanoparticulate ions to enable intracellular molecular imaging.

Award Year / Program / Phase:
2011 / SBIR / Phase II
Award Amount:
$2,387,081.00
Agency:
HHS
Principal Investigator:
John A. Schultz – (713) 522-9880
Abstract:
DESCRIPTION (provided by applicant): Within the volume of a single cell, lines an extensive amount of information. The current scope of molecular imaging using mass spectrometry typically swamps the cell volume with organic acid matrix just to get observable signals. Herein lies the problem. Putting… More

Biomarker Quantitation by NP-MS Tissue Imaging.

Award Year / Program / Phase:
2013 / SBIR / Phase II
Award Amount:
$2,954,841.00
Agency:
HHS
Principal Investigator:
John A. Schultz – 713-522-9880
Abstract:
DESCRIPTION (provided by applicant): MALDI tissue imaging, when enabled by Nanoparticulate (NP) Matrix implantation, is maturing into a useful preclinical tool for biomarker and drug discovery in our laboratory and at NIDA-IRP. Quantitatively reproducibleimages from serial coronal sections suggest… More

Gas Phase Synthesis and Implantation of Metastable Intermolecular Compounds (MICs)

Award Year / Program / Phase:
2014 / SBIR / Phase I
Award Amount:
$149,912.00
Agency / Branch:
DOD / USAF
Principal Investigator:
Ernest Lewis, Sr. Research Scientist – (713) 522-9880
Abstract:
ABSTRACT: Core-shell Metastable Intermolecular Compounds (CS-MICs) will be examined utilizing gas-phase nanocluster production, formed into an atomic beam, accelerated and implanted into polymers of interest for air stability studies as well as preliminary exothermic properties. This will include… More