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Infrared Laser Desorption Ion Mobility Mass Spectrometer

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70793
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
RR020238
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
IONWERKS, INC.
3401 Louisiana St., Suite 355 HOUSTON, TX -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Infrared Laser Desorption Ion Mobility Mass Spectrometer
Agency: HHS
Contract: 1R43RR020238-01
Award Amount: $99,944.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of this research program is to develop an infrared laser desorption ionization (IR-LDI ion mobility mass spectrometer (IMMS) for application to the analysis of biomolecules in complex systems such as direct tissue studies and the identification of the components of bioaerosols. The IMMS instrument separates biomolecule ions in two dimensions. The first dimension is the gas phase mobility separation in which the ions resulting from laser desorption drift through a gas collision cell under the influence of a constant electric field and are separated due to differences in collision cross-section. After exiting the drift cell, the ions are orthogonally extracted into a time-of-flight mass spectrometer. Because the separation takes place in the gas phase, it is significantly more rapid than liquid phase separations such as liquid chromatography or capillary electrophoresis. The performance goals for the IR-LDI IMMS are an ion mobility resolution of 50, mass resolution of 3000, mass range or 20 kDa, and a detection limit of 10 fmol. The instrument will be constructed at Ionwerks in Houston, TX. Ionwerks was founded in 1986 and is an accomplished provider of mass spectrometer systems and equipment. As part of this research, Ionwerks is collaborating with the mass spectrometry research group at Louisiana State University who are experts in the use of IR lasers for the direct analysis of biomolecules. The group will develop IMMS methods for the rapid analysis of cells and tissue with minimal sample pre-treatment. Commercial applications of this technology are in biomedical research, clinical diagnostics, and the detection of biological agents.

Principal Investigator:

Michael Ugarov
7135229880
MVU@IONWERKS.COM

Business Contact:

J. Schultz
7135229880
AL@IONWERKS.COM
Small Business Information at Submission:

IONWERKS, INC.
IONWERKS, INC. 2472 BOLSOVER, STE 255 HOUSTON, TX 77005

EIN/Tax ID: 760589694
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No