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TENNESSEE ANTIGEN IN CANCER DIAGNOSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
9326
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
9326
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Jcl Clinical Research Corp
Rt 46 Strawplains Pike Box 6275 Knoxville, TN 37914
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1988
Title: TENNESSEE ANTIGEN IN CANCER DIAGNOSIS
Agency: HHS
Contract: N/A
Award Amount: $368,000.00
 

Abstract:

A NEW TUMOR-ASSOCIATED ANTIGEN, CALLED TENNESSEE ANTIGEN (TAG), HAS BEEN ISOLATED FORM 95 PERCENT OF 154 PRIMARY HUMAN GASTROINTESTINAL TUMORS. IN 208 PATIENTS WITH COLORECTAL CARCINOMA, 81 PERCENT SHOWED ELEVATED LEVELS OF TAG IN THEIR SERA. PHASE I STUDIES RESULTED IN THE PRODUCTION OF MONOCLONAL ANTIBODIES (MOAB'S) AND THE DEVELOPMENT OF AN ENZYME-LINKED IMMUNOASSAY (EIA) TO MEASURETAG IN SERUM. IN PHASE II IT IS PLANNED TO CONTINUE TO PRODUCE AND CHARACTERIZE MOAB'S USING WESTERN BLOTTING, IMMUNOFLUORESCENCE, AND IMMUNOHISTOCHEMICAL STAINING. THE SPECIFICITY, SENSITIVITY AND REPRODUCIBILITY OF EIA WILL BE STUDIED. A PROTOTYPE OF THE TAG-EIA KIT WILL BE DEVELOPED AND THE CLINICALLY UTILITY OF THE TAG-EIA WILL ALSO BE EVALUATED. THE OBJECTIVES OF THIS PROJECT ARE TWO-FOLD: (1) UTILIZATION OF MOAB'S TO TAG AS REAGENTS IN PATHOLOGICAL EXAMINATION OF CANCERS, AND (2) COMMERCIALIZATION OF THE TAG-EIA FOR DIAGNOSIS AND MANAGEMENT OF SOLID CANCERS.

Principal Investigator:

Thomas R Potter Jr
0

Business Contact:


6155460654
Small Business Information at Submission:

Jcl Clinical Research Corp.
Rte 46,strawplains Pike P O Box 6275 Knoxville, TN 37914

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No