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IMMUNODIAGNOSTIC ASSAY FOR INVASIVE CANDIDIASIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11106
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11106
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Jcl Clinical Research Corp
Rt 46 Strawplains Pike Box 6275 Knoxville, TN 37914
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: IMMUNODIAGNOSTIC ASSAY FOR INVASIVE CANDIDIASIS
Agency: HHS
Contract: N/A
Award Amount: $45,788.00
 

Abstract:

INVASIVE AND DISSEMINATED INFECTION WITH THE FUNGAL OPPORTUNIST, CANDIDA ALBICANS, IS A FREQUENT, SERIOUS COMPLICATION ASSOCIATED WITH COMPROMISED IMMUNITY ARISING FROM DISEASE AND/OR THERAPEUTIC REGIMENS. TREATMENT FOR INVASIVE CANDIDIASIS IS AVAILABLE BUT IS DEPENDENT ON TIMELY DIAGNOSIS. THIS PROJECT WILL DEVELOP A SENSITIVE, DOUBLE-ANTIBODY ANTIGEN-CAPTURE ENZYME IMMUNOASSAY (EIA) THAT WILL DETECT CANDIDA ANTIGENS IN THE SERUM OF PATIENTS WITH CANDIDA INFECTIONS OF DEEP TISSUES. PRELIMINARY INVESTIGATION HAS RESULTED IN THE PRODUCTION OF MURINE MONOCLONAL ANTIBODIES AND GOAT ANTISERA THAT CAN SERVE AS PRIMARY AND DEVELOPING ANTIBODIES FOR THE DETECTIONOF MANNANS PRODUCED IN HOST TISSUES. FURTHER WORK WILL CONCENTRATE ON THE PRODUCTION OF MONOCLONAL AND POLYCLONAL ANTIBODIES TO SEROTYPE-SPECIFIC MANNANS OF C. ALBICANS AND TO AN ADDITIONAL INVASIVE SPECIES, C. TROPICALIS. THE ADDITIONAL REAGENTS DEVELOPED IN THIS PROJECT WILL BE USED TO FURTHER ENHANCE THE DEVELOPMENT OF SENSITIVE EIA'S FOR THE DIAGNOSIS OF INVASIVE CANDIDA INFECTIONS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Jcl Clinical Research Corp
Rt 46 Strawplains Pike Box 6275 Knoxville, TN 37914

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No