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Chloroplast Genetic Engineering to Produce Diagnostic Antigens and Vaccines

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
74042
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
A052-175-1017
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Kuehnle AgroSystems Corporation
2800 Woodlawn Drive Suite 281 Honolulu, HI 96822-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2006
Title: Chloroplast Genetic Engineering to Produce Diagnostic Antigens and Vaccines
Agency / Branch: DOD / ARMY
Contract: W81XWH-06-C-0009
Award Amount: $729,998.00
 

Abstract:

Plant chloroplasts are capable of producing significant quantities of high quality bioengineered proteins with biomedical applications. Improving the commercial supply of diagnostic antigens and vaccines through use of our pliable expression platform will provide an important technological advance compared with the current mammalian and microbial cell culture platforms. Our innovative approach combines a next-generation plant platform, for rapid line production, with established downstream processing, and a novel technology that permits site-directed insertion of one or more transgenes in chloroplasts. This platform advance has the potential for significant production of antigens, such as for the hantavirus, in contained, biosecure facilities under conditions of Good Manufacturing Practice. Production of hantaviral proteins using the technical enabling strategies developed in Phase I for our target platform is anticipated to meet the proposed Phase II goal of applying the technology collaboratively to produce sufficient quality antigens for diagnostic and immunogenicity assays.

Principal Investigator:

Michele Champagne
Senior Researcher
8087535084
kasllc@hawaii.rr.com

Business Contact:

Gordon Wallace
President
8087533170
kasllc@hawaii.rr.com
Small Business Information at Submission:

KUEHNLE AGROSYSTEMS CO. LLC
2800 Woodlawn Drive Honolulu, HI 96822

EIN/Tax ID: 990337121
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No