USA flag logo/image

An Official Website of the United States Government

DEVELOPMENT OF MULTI-DEPOT POLYMER DRUG DELIVERY SYSTEM

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60044
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
CA088585
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
KENSEY NASH CORPORATION
735 Pennsylvania Dr EXTON, PA 19341-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: DEVELOPMENT OF MULTI-DEPOT POLYMER DRUG DELIVERY SYSTEM
Agency: HHS
Contract: 1R43CA088585-01A2
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Local disease control is a problem in the management of patients with cancer. Most chemotherapeutic drugs are given to patients systemically as an adjunct to the removal of malignant tumors. Even with radiation therapy, local recurrences too often develop. Sustained or controlled release of drugs directly into wounds after the removal of malignancies may provide control of microscopic residual cancer cells, avoid system toxicity and ameliorate wound healing problems. Development of a programmable, multi-depot chemotherapeutic polymer delivery system is proposed for the treatment of breast cancer. The hypothesis for the investigation is that a bioresorbable delivery device can provide a sustained therapeutic dose of chemotherapy while decreasing system toxicity and delaying or preventing distant metastasis. Furthermore, the device can be engineered to degrade very slowly after it has delivered its payload and act as an in vivo cell culture substratum to direct the pattern of tissue development within the wound. Preliminary results using a prototype have demonstrated the potential of the proposed system. Specific aims for the Phase I program are to: Design, engineer and fabricate the construct; develop and validate the analytical system needed to obtain a basic drug release profile of the device; and conduct normal in vivo studies to assess device pharmacokinetics, local and systemic effects. PROPOSED COMMERCIAL APPLICATION: Drug delivery is rapidly becoming an integral part of drug development strategies within the pharmaceutical and biotechnology industries. By the year 2002, revenues of pharmaceutical products which utilize drug delivery systems will reach $35 Billion in the U.S. and $50 Billion worldwide, or 20% of total pharmaceutical sales.

Principal Investigator:

John H. Brekke
2187203628
J.BREKKE@KENSEYNASH.COM

Business Contact:

William Mass
6105947111
B.MAAS@KENSEYNASH.COM
Small Business Information at Submission:

KENSEY NASH CORPORATION
KENSEY NASH CORPORATION 55 E UWCHLAN AVE, STE 204 EXTON, PA 19341

EIN/Tax ID: 363316412
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No