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Automated DECT Angiography Bone Removal

Award Information

Department of Health and Human Services
Award ID:
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
Solicitation Year:
Solicitation Topic Code:
Solicitation Number:
Small Business Information
28 Corporate Drive Clifton Park, NY -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phase 1
Fiscal Year: 2009
Title: Automated DECT Angiography Bone Removal
Agency: HHS
Contract: 1R43RR028020-01A1
Award Amount: $172,255.00


DESCRIPTION (provided by applicant): This overall goal of this SBIR project is to develop a fully automated bone removal method for Dual Energy Computed Tomography (DECT) angiography scans. Dual energy scans offer the opportunity to better understand the m aterial decomposition of anatomy, thus allowing for new methods to visualize and understand a wide range of diseases and conditions. In Phase I of this proposal we will develop and evaluate the main algorithmic components of our automated bone segmentation method, evaluate the potential impact on CTA workflow, and design a prototype user interface. We will also design, conduct, and analyze a preliminary evaluation of the automatically produced bone suppressed images with respect to manual segmentations. Alg orithm development and evaluation will be performed using an existing database of dual energy clinical CT images, provided by GE Healthcare. In Phase II we will further improve the robustness of the method to include more diverse data from different dual-e nergy scanners and different anatomy, perform a larger clinical evaluation, and develop a commercial product. The ultimate goal of this work is to develop and sell this technology as an automated bone segmentation and removal product. This proposal is a pa rtnership between Stanford University, which has extensive clinical expertise in developing computational aids for medical image interpretation, and Kitware, a small business with experience in medical visualization and software development. Currently, a f ully robust and automated bone removal system does not exist, and the proposed novel solution has the potential to significantly improve current head and neck CTA interpretation making this a highly innovative and important project. The specific aims of th e research are to: 1. Develop the key components of a fully automated dual-energy CTA bone segmentation and removal method consisting of: a. An algorithm component to perform the initial decomposition of anatomy (bone, vessels, air, soft tissue) based on d ual-energy data. b. An algorithm component to recover vascular regions erroneously classified as bone by algorithm component (a). c. A final algorithm component to remove any non-vascular regions erroneously classified as vessels by the algorithm component (a) above, including the removal of partial volume bone fragments and high intensity fragments introduced by noise. 2. Develop and evaluate a prototype application incorporating these three algorithm components. The application will display the result of automated bone removal with a traditional 2D slice display and 3D MIP/volume renderings. 3. Perform a pilot study evaluating the accuracy of the automated bone removal relative to state of the art manual techniques while documenting the improvement in the workflow. PUBLIC HEALTH RELEVANCE: The goal of this project is to develop a fully automated bone removal method for Dual Energy Computed Tomography (DECT) angiography scans. The proposed DECT and algorithmic solution has the potential to significantly impr ove current head and neck CTA interpretation.

Principal Investigator:

Wes Turner

Business Contact:

Rick Avila
Small Business Information at Submission:


EIN/Tax ID: 141802694
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No