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VACCINATION AGAINST HOOKWORM WITH RECOMBINANT ANTIGENS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
45565
Program Year/Program:
1999 / SBIR
Agency Tracking Number:
1R43AI046196-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
L2 DIAGNOSTICS, LLC
BOX 8175 NEW HAVEN, CT -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1999
Title: VACCINATION AGAINST HOOKWORM WITH RECOMBINANT ANTIGENS
Agency: HHS
Contract: N/A
Award Amount: $149,657.00
 

Abstract:

Not Available Chemical weapons are highly lethal, inexpensive weapons of mass destruction. Present methods for detection of exposure to sulfur mustard are expensive and time-consuming. Accordingly, there is an urgent need for the development of rapid, simple, and reliable detection methods capable of monitoring of toxic compounds for clinical treatment and diagnosis after exposure to sulfur mustard. In phase I, we propose the syntheses of four analogs of bis ((2-acetylamino-2-carboxyethylthio) ethyl) sulfone and their conjugates with two carrier proteins (KLH and BSA) for production of antibodies and immunoassay development. Haptens will be coupled with carrier proteins through either the central sulfur atom or terminal amino group via a linker. BENEFITS: An immunoassay for rapid determination of exposure to sulfur mustard would contribute to improved diagnosis and treatment of individuals during military or terroristic acts.

Principal Investigator:

Raymond A. Koski

Business Contact:


2037852453
MJMATT@IX.NETCOM.COM
Small Business Information at Submission:

L-TWO DIAGNOSTICS, LLC
BOX 8175 NEW HAVEN, CT 94904

EIN/Tax ID: 061509946
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No