USA flag logo/image

An Official Website of the United States Government

A NOVEL MICROBIAL CELL IMMOBILIZATION PROCEDURE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
1358
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
1358
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Lawton Scientific Inc.
52 Chapman Road W.hartford, CT 06107
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: A NOVEL MICROBIAL CELL IMMOBILIZATION PROCEDURE
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

INVESTIGATIONS ARE TO BE CONDUCTED ON A NEW CELL IMMOBILIZATION PROCEDURE TO PRODUCE UNIQUE BIOCATALYSTS USING LATEX COATINGS ON ACTIVATED CARBON. IN CONTRAST TO PREVIOUSLY TRIED METHODS, OUR METHOD GIVES A POROUS SUPPORT ALLOWING RAPID SUBSTRATE AND GAS TRANSFER, HAS A HARD SURFACE TO AVOID COMPRESSION IN LARGE BEDS, AND IS DENSE TO ALLOW USE IN FLUIDIZED BEDS. PHASE I STUDIES WILL CONCENTRATE ON A) DEMONSTRATING THE BROAD SPECTRUM CAPABILITIES OF THIS METHOD BY IMMOBILIZING TWO ORGANISMS (S. CEREVISIAE B. SUBTILIS) USEFUL FOR PRODUCING RECOMBINANT DNA PROTEINS AND A MONOCLONAL ANTIBODY PRODUCING HYBRIDOMA (CPG HYBRIDOMA), B) OPTIMIZING THE PROCEDURE FOR THE FIRST TWO ORGANISMS, AND C) MAKE SHORT TERM MEASUREMENTS OF BIOCATALYST LIFE. PRODUCT FORMATION (ETHANOL, L-TRYPTOPHAN, ANTIBODY) WILL BE ASSAYED BY SUITABLE ANALYTICAL TECHNIQUE TO INDICATE THE SUCCESS OF THE IMMOBILIZATION. THE ANTICIPATED RESULT FROM PHASE I WILL CHIEFLY BE A PROVEN METHOD FOR THE IMMOBILIZATION OF THREE MEDICALLY IMPORTANT MICRO-ORGANISMS. THIS RESEARCH WILL TEST THE FEASIBILITY OF THE PROPOSED CONCEPT AND WILL ALLOW US TO GATHER ADDITIONAL RESEARCH DATA IN PHASE II THAT CAN BE USED TO DESIGN COMMERCIAL CATALYST IN PHASE III. THIS TECHNOLOGY PROVIDES THE POTENTIAL FOR THE LARGE SCALE PRODUCTION OF RDNA PROTEINS AND MONOCLONAL ANTIBODIES.

Principal Investigator:

Carl W. Lawton
President
0

Business Contact:

Small Business Information at Submission:

Lawton Scientific Inc.
52 Chapman Road W.hartford, CT 06107

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No