USA flag logo/image

An Official Website of the United States Government

Company Information:

Company Name: Le Research, Inc.
City: St. Paul
State: MN
Zip+4: 55172
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $594,268.00 8
SBIR Phase II $1,111,754.00 3

Award List:

SYNTHESIS OF LABELED LACTATE

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $39,657.00
Abstract:
Stable isotope-labeled tracers for studies of metabolic regulation and diseases are generally available from variouscommercial sources but at high costs. new preparative methods involving fewer and more convenient steps and less expensive isotope-enriched starting materials are being developed for… More

SYNTHESES OF 13C-LABELED POLYUNSATURATED FATTY ACIDS

Award Year / Program / Phase: 1991 / SBIR / Phase I
Agency: HHS
Principal Investigator: Le, Diem D , Principal Investigator
Award Amount: $47,779.00

SYNTHESES OF 13C-LABELED POLYUNSATURATED FATTY ACIDS

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Le, Diem D , Principal Investigator
Award Amount: $328,758.00
Abstract:
A number of polyunsaturated fatty acids (pufa) are either essential for a normal development of the human body or potential prophylactic/therapeutic agents for atherosclerosis, rheumatoid arthritis, carcinogenesis, type i diabetes, premature birth and low birth-weight, and abnormal development of… More

Syntheses of New Nitrones as Spin Traps

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Diem Le
Award Amount: $74,990.00
Abstract:
Nitrone spin traps such as PBN, DMPO, and 4-POBN have made possible in vivo detection ofxenobiotic metabolites as radical adducts. Some of their deuterated and methylated analogs were foundor predicted to greatly improve the resolution and sensitivity of ESR or stability of the adducts, and mayallow… More

Development of C Labeled Nitrons

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Diem Le
Award Amount: $93,083.00
Abstract:
Some nitrone spin traps have been found to possess many potentially useful pharmacological propertilowering septic shock fatality, reversing the effects of aging, cardioprotection, and vasodilation.dispositon and metabolism in the development of these compounds as new drugs require the nitrone… More

Carbon-13 Labeled Nucleosides and Nucleotides

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Diem Le
Award Amount: $87,966.00
Abstract:
Stable-isotope labeled nucleosides or nucleotides were identified as crucial for further advances istructures and dynamics of DNA's and RNA's. Investigators in this field have suggested nucleosides/-C-l',3',5' as most useful and cost-effective. This Phase I project aims to synthesize… More

Asymmetric Syntheses of Carbon 13 Labeled Amino Acids.

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Diem Le
Award Amount: $79,690.00

Asymmetric Syntheses of Carbon 13 Labeled Amino Acids.

Award Year / Program / Phase: 1996 / SBIR / Phase II
Agency: HHS
Principal Investigator: Diem Le
Award Amount: $691,949.00
Abstract:
New production methods for stable-isotope labeled amino acids that are suitable for NMR structuralmembrane proteins were identified as necessary for further advances in this field. Phase I aims to eSchoellkopf's lactim alkylation method for commercial L-tyrosine-3-13C, L-leucine-4-13C, and… More

DEVELOPMENT OF PERDEUTERATED NITROSO SPIN TRAPS

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $81,291.00

DEVELOPMENT OF ADDUCTPPERSISTENT SPIN TRAPS/SUPEROXIDE

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Le, diem
Award Amount: $89,812.00

Syntheses of 14 C Labeled Nitrone Spin traps

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $91,047.00