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SUPERCRITICAL FLUID CHROMATOGRAPHY OF CANNABINOIDS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3345
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
3345
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Lee Scientific Inc
4426 S Century Dr Salt Lake City, UT 84123
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: SUPERCRITICAL FLUID CHROMATOGRAPHY OF CANNABINOIDS
Agency: HHS
Contract: N/A
Award Amount: $213,000.00
 

Abstract:

THE ANALYSIS OF CANNABINOIDS FOR RESEARCH OR SCREENING FOR CANNABIS ABUSE REQUIRES METHODS CAPABLE OF CHARACTERIZING AND QUANTIFYING METABOLITES OF THE CANNABINOIDS WHICH ARE GENERALLY POLAR OR THERMALLY UNSTABLE AND WHICH MUST BE SEPARATED FROM A COMPLEX BIOLOGICAL MATRIX. SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) IS PROPOSED AS A METHOD WHICH IS CAPABLE OF PROVIDING HIGH-RESOLUTION SEPARATION OF POLAR OR THERMALLY LABILE COMPOUNDS WITH OPTIMUM DETECTION CAPABILITY WHILE REQUIRING MINIMAL PRESEPARATION. ADVANTAGES OF USING SFC ARISE FROM HIGH SOLUTE DIFFUSIVITY, LOW VISCOSITY, AND EXCELLENT SOLVATION CAPABILITY. THIS STUDY INTENDS TO DEMONSTRATE THE EFFECTIVENESS OF SFC IN ANALYSIS OF CANNABINOID METABOLITES. TO SUPPORT THE DEVELOPMENT OF METHODS AND SFC EQUIPMENT FOR ANALYSIS OF THESE POLAR COMPOUNDS, RESEARCH WILL BE DIRECTED TOWARD EVALUATION OF BONDED PHASE CAPILLARY COLUMNS, DETERMINATION OF METABOLITE SOLUBILITY IN VARIOUS CANDIDATE SUPERCRITICAL FLUIDS, DETERMINATION OF EXTRACTION PROFILES OF METABOLITES, AND A DETERMINATION OF CONDITIONS AFFECTING SENSITIVITY OF SFC DETECTORS PROPOSED FOR DEVELOPMENT. THE OBJECTIVE OF THIS RESEARCH IS THE DEVELOPMENT OF METHODS AND INSTRUMENTATION WHICH WILL BE READILY APPLIED TO RESEARCH AND SCREENING ACTIVITIES AND WHICH ARE OPERABLE BY RESEARCH AND CLINICAL LABORATORY STAFF TRAINED IN STANDARD GC OR LC CHROMATOGRAPHIC TECHNIQUES.

Principal Investigator:

Douglas W. Later
Principal Investigator
8012612300

Business Contact:

Small Business Information at Submission:

Lee Scientific, Inc.
4426 South Century Drive Salt Lake City, UT 84123

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No