DESCRIPTION (provided by applicant): This project seeks to address a particular unmet need for mechanical circulatory support in children with heart failure. Pediatric heart patients possess several unique features, such as small body size, reduced blood volume, and altered hemodynamic… More

DESCRIPTION (provided by applicant): The prevalence of congestive heart failure in the United States is nearly 5 million patients, with more than 500,000 new cases diagnosed per year. Of these patients, approximately 400,000 have a life expectancy of less than one year, and 200,000 die each year… More

DESCRIPTION (provided by applicant): The photolytic Conversion of energy derived from light is a common means in nature to drive chemical reactions. As an example, photosynthesis utilizes energy derived from sunlight to drive key metabolic processes in plants, while exchanging oxygen for carbon… More

DESCRIPTION (provided by applicant): Our goal is to create an affordable ventricular assist device, capable of meeting the needs of a broad range of patients with severe heart failure. The focus of this project will be to develop a miniature, low-cost, ventricular assist device, suitable for use for… More

DESCRIPTION (provided by applicant): The death rate due to respiratory disease has increased nearly 20% in the United States since 1979, surpassing virtually all other types of disease. Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a… More

DESCRIPTION (provided by applicant): The objective of this work is to transition the development of a ventricular assist system designed to support neonates and small children from animal testing into a single center clinical trial. The 2001 report of the NHLBI) sponsored Task Force on Research in… More

DESCRIPTION (provided by applicant): Chronic lung disease remains America's third largest cause of death. Adult respiratory distress syndrome (ARDS) alone afflicts approximately 150,000 patients every year with a mortality rate between 30-70%. Current ther apy for respiratory failure includes… More

DESCRIPTION (provided by applicant): The objective of this research plan is to transition the development of the UltraMag ventricular assist system, which is designed to support neonates and small children, from the preclinical to the clinical trial phase. The work will culminate in a single… More