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PROLONGED PRESERVATION OF HUMAN PLATELETS FOR COMBAT CASUALTY CARE

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 15099
Amount: $741,232.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1993
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
3606a Research Forest Drive
The Woodlands, TX 77381
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Stephen A Livesey Md
 Principal Investigator
 (713) 367-5368
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE AIM OF THIS PROPOSAL IS TO DEVELOP PROTOCOLS FOR THE LONG-TARTS CRYOPRESERVATION OF HUMAN PLATELETS FOR TRANSFUSION. OPTIMIZATION OF PLATELET ISOLATION AND CRYOPRESERVATION WILL BE COMBINED WITH SPECIFIC MODULATION OF STIMULUS RESPONSE COUPLING MECHANISMS IN THE PLATELET. THE EFFECTIVENESS OF THE PROCESSING PROCEDURE WILL BE MONITORED BY NUMERICAL RECOVERY, MORPHOLOGY AND IN VITRO FUNCTIONALITY. IN ADDITION, ANALYSIS OF SECOND MESSEAGER RESPONSE MECHANISMS BY A NEWLY ESTABLISHED CRYOELECTRON MICROSCOPIC TECHNIQUE WILL CONSIDERABLY ENHANCE ANALYSIS AND FACILITATE INTERPRETATION OF PLATELET MODIFICATIONS. THIS APPROACH HAS THE POTENTIAL TO GREATLY EXTEND THE CURRENT LIQUID PRESERVATION OF PLATELETS AND ENABLE LONG-TERM CRYOPRESERVATION, THEREBY ADDRESSING THE MAJOR CURRENT PROBLEMS OF PLATELET TRANSFUSION. CRYOPRESERVATION OF PLATELETS HAS SPECIFIC APPLICATION TO COMBAT MEDICAL SUPPORT AND AUTOLOGOUS PLATELET TRANSFUSION IN CHEMOTHERAPY. CRYOPRESERVATION AND PROLONGED LIQUID PRESERVATION HAS APPLICATION TO PLATELET SUPPLY IN GENERAL.

* Information listed above is at the time of submission. *

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