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MULTIVALENT ANTIGEN EXPRESSION AND VACCINE FOR MALARIA

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60522
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI051752
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
LIFESENSORS, INC.
271 GREAT VALLEY PKY MALVERN, PA -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: MULTIVALENT ANTIGEN EXPRESSION AND VACCINE FOR MALARIA
Agency: HHS
Contract: 1R43AI051752-01
Award Amount: $637,087.00
 

Abstract:

DESCRIPTION: (Provided by Applicant) Malaria continues to be one of the devastating diseases affecting a large population of the world and claims an estimated one to two million lives annually. Unfortunately, there is no vaccine available against malaria. Current recombinant vaccine candidates are only of one or of few antigens that block one stage in the malaria life cycle and are proven not to be effective. We propose combinatorial approach by using yeast and baculovirus to express at least 30 antigens using ubiquitin-fusion technology that targets all three steps in malaria life cycle. Multiple antigens can now be expressed rapidly using new cloning technologies. LifeSensors proposes the attachment of ubiquitin to C-terminus of candidate malaria antigens to dramatically enhance quality and quantity of the proteins. Besides the improvement of protein expression and folding, ubiquitin fusion technique allows to generate proteins with different amino termini and a choice to create uncleaved Ub-antigens. The latter has been shown to increase CTL response upon immunization. The pool of antigens will be tested in mice for immune response, as well as immunofluorescence studies with P. falciprum to localize the antigen interaction. Phase II of this SBIR will include an increase in number of antigens, production of clinical grade material, as well as tests in monkey model. We believe that a highly efficient method of expression of multiple and ubiquitinated antigens will be a novel solution in the development of malaria vaccine.

Principal Investigator:

Tauseef R. Butt
6106448845
BUTT@LIFESENSORS.COM

Business Contact:

Tauseef Butt
6106448845
WWW.LIFESENSORS.COM
Small Business Information at Submission:

LIFESENSORS, INC.
LIFESENSORS, INC. 271 GREAT VALLEY PKY MALVERN, PA 19355

EIN/Tax ID: 232855125
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No