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All Solid State Laser for DNA Sequencing

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25274
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
25274
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
LIGHTWAVE ELECTRONICS CORPORATION
LIGHTWAVE ELECTRONICS CORP. 2400 CHARLESTON RD MOUNTAIN VIEW, CA 94043
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: All Solid State Laser for DNA Sequencing
Agency: HHS
Contract: 1 R43 RR09853-1,
Award Amount: $78,620.00
 

Abstract:

Numerous biomedical analysis techniques utilize laser-induced-fluorescence detection. Thisprovides a high sensitivity analysis tool for biomedical research and clinical diagnosis. The mostcommonly used laser for these applications is the Ar-ion laser, since it is well matched to the excitationwavelengths of the most widely used dyes. However this laser is less than optimal for theseapplications: it is fairly large and has low efficiency, so it dissipates much excess heat in the instrumentand consumes substantial electrical power. It also has limited lifetime, so regular repair is necessary.This Phase I aims to investigate the feasibility of developing a compact, efficient, robust, long-lifetimelaser source that would be a superior, cost-effective replacement for Ar-ion lasers in biomedicalinstrumentation. It would be based on new InGaAs diode lasers. The near-infrared output of such adiode would he frequency-doubled in a nonlinear crystal to achieve a wavelength of 510 nm, which isoptimal for DNA sequencing. We will use a resonant doubling cavity to achieve good conversionefficiency. The Phase II follow-on would entail developing a 510 nm source optimized for use in DNAsequencers and other biomedical instruments.

Principal Investigator:

Thomas Steele
4159620755

Business Contact:

Small Business Information at Submission:

Lightwave Electronics Corp.
1161 San Antonio Road Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No