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All-Solid-State Laser for Biomedical Instrumentation

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22409
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22409
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
LIGHTWAVE ELECTRONICS CORPORATION
LIGHTWAVE ELECTRONICS CORP. 2400 CHARLESTON RD MOUNTAIN VIEW, CA 94043
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: All-Solid-State Laser for Biomedical Instrumentation
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

Numerous biomedical analysis techniques, such as flow cytometry and confocal microscopy, utilize laser-induced-fluorescence detection. This provides a high sensitivity analysis tool for biomedical research and clinical diagnosis. The most commonly used laser for these applications is the 488nm Ar-ion laser, since it is well- matched to the excitation wavelength of fluorescein dyes which are the most widely used. However, this laser is less than optimal for these applications: it is fairly large, has low efficiency, it dissipates excess heat in the instrument, and consumes substantial electrical power. It also has limited lifetime, so regular repair is necessary. This Phase I aims to investigate the feasibility of developing a compact, efficient, robust, long-lifetime laser source that would be a superior, cost-effective replacement for Ar-ion lasers in biomedical instrumentation. It would be based on new InGaAs disde lasers. The near-infrared output of this device would be frequency-doubled in a nonlinear crystal to achieve a wavelength of approximately 490nm, optimal for these applications. We will use a resonant doubling cavity to achieve good conversion efficiency. The Phase II follow-on would entail developing a 490nm source optimized for use in biomedical instruments.

Principal Investigator:

Thomas R. Steele
4159620755

Business Contact:

Small Business Information at Submission:

Lightwave Electronics Corp.
1161 San Antonio Road Mountain View, CA 94043

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No