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THE PRIMARY TREATMENT FOR GALLSTONES IS SURGICAL REMOVAL.

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4884
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4884
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Lipid Specialties Inc
21 Tioga Way Marblehead, MA 01945
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE PRIMARY TREATMENT FOR GALLSTONES IS SURGICAL REMOVAL.
Agency: HHS
Contract: N/A
Award Amount: $34,000.00
 

Abstract:

THE PRIMARY TREATMENT FOR GALLSTONES IS SURGICAL REMOVAL. WITH A 1% MORTALITY RATE AND SUBSTANTIAL HOSPITALIZATION COSTS, A SEARCH FOR LESS EXPENSIVE AND SAFER TREATMENTS FOR GALLSTONE ELIMINATION IS WARRANTED. IT HAS BEEN SHOWN THAT GALLSTONES CONSIST PRIMARILY OF CHOLESTEROL AND THAT THEIR FORMATION IS A CONSEQUENCE OF EXCEEDING THE SOLUBILITY LIMITS OF CHOLESTEROL IN THE BILE. AS A RESULT, IT HAS BEENPROPOSED THAT ORAL TREATMENT WITH SUITABLE BILE ACIDS MAY ACT AS GALLSTONE DISSOLVING AGENTS, THEREBY ELIMINATING THE NEED FOR SURGERY. THE GOAL OF THIS PROJECT IS TO DEMON- STRATE THAT SHORT CHAIN ANALOGS OF HEAD GROUP MODIFIED PHOSPHATIDYLCHOLINES HAVE SUPERIOR SOLUBILIZING PROPERTIES WHEN COMPARED TO OTHER POTENTIAL CHOLESTEROL SOLUBILIZING AGENTS AND RELATIVE TO THE AMOUNT AND SPEED AT WHICH THEY CAN DISSOLVE PRE-EXISTING CHOLESTEROL CRYSTALS. SHOULD PHASE I STUDIES BE SUCCESSFUL, PHASE II STUDIES WOULD THEN CONCENTRATE ON THE ABILITY OF MODIFIED PHOSPHATIDYLCHOLINES TAKEN ORALLY TO ENTER INTO THE ENTEROHEPATIC CIRCULATION IN ANIMAL MODELS. FUTURE TESTING WOULD CONSIST OF PRELIMINARY HUMAN STUDIES.

Principal Investigator:

Dr barry sears
PRINCIPAL INVESTIGATOR
6176392400

Business Contact:

Small Business Information at Submission:

Lipid Specialties
21 Tioga Way Marblehead, MA 01945

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No