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A HOMOGENEOUS ASSAY FOR MIXED CONNECTIVE TISSUE DISEASE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7866
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7866
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Lipogen Inc
10515 Research Dr Knoxville, TN 37923
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: A HOMOGENEOUS ASSAY FOR MIXED CONNECTIVE TISSUE DISEASE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

WE PROPOSE TO DEVELOP A HOMOGENEOUS, LIPOSOME-BASED IMMUNOASSAY FOR ANTINUCLEAR ANTIBODY (ANA) DISEASES. IN THE PHASE I STUDIES, WE WILL DEMONSTRATE THE FEASIBILITY OF THE APPROACH FOR ONLY ONE ANA DISEASE, I.E., THE MIXED CONNECTIVE TISSUE DISEASE. THE MAJOR NUCLEAR ANTIGEN U1-RNP, FOR THIS AUTOIMMUNE DISEASE HAS BEEN CLONED IN BACTERIA WITH A PROPRIETARY TECHNOLOGY. WE WILL INCORPORATE THE CLONED U1-RNP INTO LIPOSOME MEMBRANE TO PREPARE TARGET-SENSITIVE LIPOSOMES (ALSO A PROPRIETARY TECHNOLOGY OF LIPOGEN, INC.). GLUCOSE-6-PHOSPHATE DEHYDROGENASE WILL BE ENTRAPPED AS A REPORTER ENZYME. A HOMOGENEOUS, COLORIMETRIC, INHIBITION ASSAY WILL BE DEVELOPED AS A PROTOTYPE FOR FUTURE DIAGNOSTIC PRODUCTS WHICH WILL INCLUDE OTHER ANA ANTIBODIES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Lipogen Inc
10515 Research Dr Knoxville, TN 37923

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No