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Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80324
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
CA117093
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
LITRON LABORATORIES, LTD.
200 CANAL VIEW BLVD, STE 106 ROCHESTER, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Rapid Screen for Genotoxicants, Chemoprotectors, and Radioprotectors
Agency: HHS
Contract: 1R43CA117093-01A1
Award Amount: $133,336.00
 

Abstract:

DESCRIPTION (provided by applicant): This research project addresses an important problem faced by the chemical and drug industries? their requirement to evaluate the DNA damaging potential of ever larger numbers of new chemical entities in shorter periods of time. This situation presents opportunities for small businesses that are able to provide solutions to these challenges. The work proposed herein addresses industry's need for higher throughput toxicity assessment through the development of an automated in vitro chromosomal damage assay. Chromosome damage will be quantified by flow cytometric micronucleus measurements. Importantly, the methodology that will be developed over the course of this project not only represents a high volume genotoxicant screening system, but also one that can be configured to identify agents which protect against chromosomal damage. This project addresses a stated need of investigators working to develop the next generation of biological response modifiers (BRMs). BRMs that provide chemo- or radio-protection hold great promise in several important arenas, including cancer treatments which are typically dose-limited by normal tissue responses. The identification and development of BRMs have other important applications, and include enhanced protection of our troops during times of war, and also for civilian victims of chemical or radiological terrorist attacks. The planned Phase 1 and Phase 2 efforts have thus been designed to provide a rapid and efficient assay for detecting the genotoxicant, radioprotectant, or chemoprotectant potential of test chemicals. This screening assay will help chemical and drug companies allocate their resources to the most promising candidates, eliminating hazardous entities early in development. Furthermore, by aiding in the identification of next generation BRMs, cancer patients and armed forces will benefit from the availability of chemo- and radio-protectant drugs

Principal Investigator:

Stephen D. Dertinger
5854420930
SDERTINGER@LITRONLABS.COM

Business Contact:

Carol Tometsko
5854420930
CAROLTOMET@AOL.COM
Small Business Information at Submission:

LITRON LABORATORIES, LTD.
200 Canal View Blvd. SUITE 106 ROCHESTER, NY 14623

EIN/Tax ID: 161080732
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No