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Micro/Nano-Encapsulation of Partial Oxidation Biocatalysts

Award Information

Agency:
Department of Energy
Branch:
N/A
Award ID:
72378
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
78011S05-I
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
LNKCHEMSOLUTIONS
4701 INNOVATION DRIVE LINCOLN, NE -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Micro/Nano-Encapsulation of Partial Oxidation Biocatalysts
Agency: DOE
Contract: DE-FG02-05ER84326
Award Amount: $99,999.00
 

Abstract:

78011S Many industrial liquid-phase catalytic processes that require the use of some kind of active species (e.g. sensors, biosensors, chelating agents, and chemical traps) cannot be ¿heterogeneized¿ without significantly penalizing chemical activity and/or selectivity. Biphasic liquid media strategies are an alternative, but these rely heavily on confinement of the active species in one of the two phases, potentially compromising the frequency of substrate/catalyst molecular encounters. This project will develop technology for the micro- and/or nano-encapsulation of a liquid-phase core containing the catalytic species inside a porous ¿egg-shell¿ structure. The capsules will function as micro- or nanoreactors, allowing diffusion of substrates, products and solvents through their porous shells and in and out of their cores, while keeping bulky catalytic species encaged to facilitate subsequent catalyst-product separation steps. In principle, this should lead to utilization of the oxidation biocatalyst in its most effective (non-immobilized) state, while minimizing the number of post-reaction separation steps. Phase I will manufacture and conduct preliminary testing of one core-shell material for partial oxidation catalysis. The system will be based on a core containing dissolved enzymes and a hybrid (organic/inorganic) porous shell. Commercial Applications and Other Benefits as described by the awardee: The technology should maintain the activity and selectivity of the biocatalyst at the highest possible levels while still providing a means for facilitating any potential post-reaction separation step. Besides the specific catalytic process being targeted, a similar approach should be applicable to asymmetric and enzyme catalysis for fine chemicals synthesis.

Principal Investigator:

Gustavo F. Larsen
Dr.
4024161811
LNKChemsolutions@netscape.net

Business Contact:

Gustavo F. Larsen
Dr.
4024161811
LNKChemsolutions@netscape.net
Small Business Information at Submission:

Lnkchemsolutions
2411 Winchester South Lincoln, NE 68512

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No