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STATISTICALLY VALID PROCEDURES WILL BE DEVELOPED FOR A READILY ACCESSIBLE,…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3295
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3295
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Loats Associates, Inc.
201 East Main St. Westminster, MD 21157 0520
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: STATISTICALLY VALID PROCEDURES WILL BE DEVELOPED FOR A READILY ACCESSIBLE, USER-FRIENDLY PC-BASED SYSTEM TO QUANTITATIVELY ANALYZE AND CORRELATE SERIAL IMAGES FROM RADIOLABELED BRAIN SECTIONS.
Agency: HHS
Contract: N/A
Award Amount: $47,684.00
 

Abstract:

STATISTICALLY VALID PROCEDURES WILL BE DEVELOPED FOR A READILY ACCESSIBLE, USER-FRIENDLY PC-BASED SYSTEM TO QUANTITATIVELY ANALYZE AND CORRELATE SERIAL IMAGES FROM RADIOLABELED BRAIN SECTIONS. THE UTILITY OF THESE PROCEDURES WILL BE ESTABLISHED BY THE CORRELATIVE ANALYSIS OF THE EFFECT OF OPIATE DEPENDENCE AND WITHDRAWAL IN RECONSTRUCTION OF SERIAL IMAGES AVOIDS PROBLEMS INVOLVED IN SAMPLING SO-CALLED REPRESENTATIVE TISSUE SECTIONS. NEUROCHEMICAL HETEROGENEITY WITHIN MORPHOLOGICALLY HOMOGENEOUS REGIONS CAN BE EASILY DISCERNED AND REGIONAL CHARACTERISTICS CAN BE VIEWED AS A PART OF A NEURAL SYSTEM RATHER THAN ISOLATED CELL GROUPS. SECOND, RECONSTRUCTION MAKES COMPARISONS BETWEEN ANIMALS MORE RELIABLE BY PRESENTING DATA IN A 3-D ARRAY WHERE COORDINATES RELATE TO SPECIFIC ANATOMICAL LANDMARKS. THIRD, THE PRECISION OF THE QUANTITATIVE PROCEDURES CAN BE INCREASED SINCE THE DATA WITHIN A SPECIFICALLY DEFINED REGION CAN BE INTEGRATED. FINALLY, SINCE MAPPING STATISTICS CAN BE APPLIED, THE RELATION BETWEEN THE FEATURES OBTAINED USING THE DIFFERENT PROCEDURES CAN BE RELIABLY QUANTITATED AND VERIFIED. THUS, EXPERIMENTS THAT WERE PREVIOUSLY PROHIBITIVE, DUE TO THE LABOR-INTENSIVE PROCEDURES INVOLVED, CAN BE ACCOMPLISHED AND ANATOMICAL AND NEUROCHEMICAL DATA THAT COULD PREVIOUSLY ONLY BE ANECDOTALLY RELATED

Principal Investigator:

James r. unnerstall
PRINCIPAL INVESTIGATOR
3018768055

Business Contact:

Small Business Information at Submission:

Loats Associates, Inc.
24 Court Street Westminster, MD 21157

EIN/Tax ID: 521241956
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No