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COLOR BASED AUTOMATED MICRONUCLEI ASSAY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
16578
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
16578
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Loats Associates, Inc.
201 East Main St. Westminster, MD 21157 0520
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Woman-Owned: Yes
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1993
Title: COLOR BASED AUTOMATED MICRONUCLEI ASSAY
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THIS PROJECT IS FOR THE DEVELOPMENT OF AN AUTOMATED COLOR BASED MICRONUCLEI ASSAY SYSTEM BASED ON RESULTS OF A PROTOTYPE MS-DOS COLOR ANALYSIS SYSTEM. THE SYSTEM WILL AUTOMATICALLY LOCATE AND COUNT POLYCHROMATIC ERYTHROCYTES (PCE'S), MICRONUCLEATED POLYCHROMATIC ERYTHROCYTES (MPCES) AND NORMOCHROMATIC ERYTHROCYTES (NCES). DURING PHASE I, A NUMBER OF CRITICAL VARIABLE PARAMETERS PREVIOUSLY DEVELOPED WILL BE ADAPTED INTO A USER-FRIENDLY INTERACTIVE PROGRAM CAPABLE OF RAPIDLY SELECTING THE APPROPRIATE PARAMETERS FOR EACH NEW SLIDE PREPARATION. THESE PARAMETERS INCLUDE: THE LEVEL OF BACKGROUND STRAIN; CRITERIA FOR ACCEPTABLE ERYTHROCYTE SIZE RANGE AND ROUNDNESS; AND COLOR DISCRIMINATION. COLOR DISCRIMINATION IS THE KEY ELEMENT FOR DIFFERENTIATION. THE SYSTEM WILL BE IMPLEMENTED ON A MACINTOSH IIFX COMPUTER. IT WILL INCLUDE A CAPABILITY TO AUTOMATICALLY PROCESS MULTIPLE SLIDES AND PRODUCE AUTOMATIC REPORTS INCLUDING APPROPRIATE STATISTICAL ANALYSIS. BY CAPTURING ALL IMAGES WITH SCORED MICRONUCLEI THE SYSTEM PROVIDES A NECESSARY AUDIT TRAIL FOR REGULATORY OVERVIEW.

Principal Investigator:

Loats, Harry L
Principal Investigator
4108768055

Business Contact:

1 r43 es05872-01
Small Business Information at Submission:

Loats Associates, Inc.
1004 Littlestown Pike Westminster, MD 21157

EIN/Tax ID: 521241956
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No